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Biomarkers of response to ocrelizumab in relapsing-remitting multiple sclerosis.
Front Immunol
November 2024
Immunology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.
Objective: To ascertain the changes of serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) values in relapsing-remitting multiple sclerosis (RRMS) patients treated with ocrelizumab and their association with treatment response.
Methods: Multicenter prospective study including 115 RRMS patients initiating ocrelizumab treatment between February 2020 and March 2022 followed during a year. Serum samples were collected at baseline and every 3 months to measure sNfL and sGFAP levels using single-molecule array (SIMOA) technology.
XXII Moscow Scientific and Practical Conference "Otorhinolaryngology: Traditions and Modernity", dedicated to the 100th anniversary of the birth of Professors Liya Borisovna Daynyak and Boris Mikhailovich Sagalovich. Part 2.
View Article and Find Full Text PDFSerum vitamin B12 concentration is associated with improved memory in older individuals with higher adherence to the Mediterranean diet.
Clin Nutr
December 2023
Institut de Nutrició i Seguretat Alimentària (INSA), Universitat de Barcelona (UB), 08921 Santa Coloma de Gramanet, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain; Department of Internal Medicine, Hospital Clinic, Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), University of Barcelona, 08036 Barcelona, Spain. Electronic address:
Article Synopsis
- Vitamin B is linked to cognitive performance, but its effectiveness may depend on the presence of other nutrients like folate and adherence to the Mediterranean diet.
- A study involving 170 older participants showed a strong correlation between serum vitamin B levels and memory function among those with high adherence to the Mediterranean diet, while the link was weaker for those with lower adherence.
- High adherence to the Mediterranean diet was associated with increased serum folate levels, indicating that dietary patterns influence cognitive function beyond just vitamin B intake.
Urinary metabolomics of phenolic compounds reveals biomarkers of type-2 diabetes within the PREDIMED trial.
Biomed Pharmacother
June 2023
Polyphenol Research Group, Departament de Nutrició, Ciències de l'Alimentació i Gastronomia, Universitat de Barcelon (UB), Av. de Joan XXII, 27-31, 08028 Barcelona, Spain; Institut de Nutrició i Seguretat Alimentària (INSA), Universitat de Barcelona (UB), Santa Coloma de Gramanet, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain. Electronic address:
Background: Phenolic compounds have been associated with protective effects against type-2 diabetes (T2D). We used a metabolomics approach to determine urinary phenolic metabolites associated with T2D and fasting plasma glucose.
Methods: This case-control study within the PREDIMED trial included 200 participants at high cardiovascular risk, 102 of whom were diagnosed with T2D.
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