Cutaneous melanoma is the deadliest skin cancer showing an increasingly growing incidence in white populations of Europe and United States. Intensive research in recent years has begun to unlock its molecular pathogenesis. Screening the neoplasm at an early stage remains primordial. Hence, targeting populations at risk is likely efficient. In such an attempt, the regular clinical examination benefits from a series of non invasive procedures such as skin surface biopsies, in vivo confocal microscopy, dermoscopy and specular fluorescent light reflectance.
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Thirty years of StAR gazing: expanding the universe of the steroidogenic acute regulatory protein.
J Endocrinol
January 2025
W L Miller, Department of Pediatrics, Center for Reproductive Sciences, and Institute for Human Genetics University of California, San Francisco, United Kingdom of Great Britain and Northern Ireland.
Current understanding of the biology, biochemistry and genetics of the steroidogenic acute regulatory protein (StAR) and its deficiency state (congenital lipoid adrenal hyperplasia, lipoid CAH) involves the complex interplay of four areas of study: the acute regulation of steroidogenesis, clinical phenomena in lipoid CAH, the enzymatic conversion of cholesterol to pregnenolone in steroidogenic mitochondria, and the cell biology of StAR. This review traces the origins of these areas of study, describes how they have been woven into an increasingly coherent fabric, and tries to explore some remaining loose ends in this ongoing field of endocrine research. Abundant research from multiple laboratories establishes that StAR is required for the rapid, abundant steroidal responses of the adrenals and gonads, but all steroidogenic cells, especially the placenta, have StAR-independent steroidogenesis, whose basis remains under investigation.
View Article and Find Full Text PDFGazing into the crystal ball: Do adolescent survival expectations predict premature mortality risk in the United States?
Soc Sci Med
January 2025
The Carolina Population Center, University of North Carolina at Chapel Hill, 123 W. Franklin St., Chapel Hill, NC, 27516, USA.
A robust body of research has demonstrated that adolescents' survival expectations are predictive of important facets of their young adult lives. Specifically, adolescent perceptions of a low chance of surviving to young adulthood are associated with worse physical and mental health, higher engagement in risky behaviors, and lower socioeconomic status in young adulthood. Using data from a nationally representative sample of adolescent participants in the National Longitudinal Study of Adolescent to Adult Health, the purpose of the present study is to extend this line of research by investigating if adolescents' survival expectations are associated with premature (ages 14-46) all-cause mortality risk in the United States.
View Article and Find Full Text PDFNoninvasive programmed stimulation after ventricular tachycardia ablation: gazing into a crystal ball to predict recurrences?
J Interv Card Electrophysiol
August 2024
Electrophysiology Section, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.
"It's like crystal gazing": The Lived Experience of Anticipating End-of-Life Choices in Older Adults and Their Close Ones.
Gerontologist
July 2024
Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Background And Objectives: Nowadays people increasingly try to take control over the end of their lives by anticipating end-of-life choices. Explication of these choices is encouraged using advance care planning (ACP). We aim to deepen our understanding of how choice-making processes are lived in real life, exploring the experience of community-dwelling older adults and their close ones over time.
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