AI Article Synopsis
- The study examined how deuterium/protium (D/H) isotope exchange affects morphological and functional indices in rats, particularly under chronic endotoxicosis conditions.
- Results showed that lowering deuterium in the rats' water led to a 32-36% decrease in blood plasma deuterium levels and a 13-17% decrease in major organs like the liver and kidneys.
- This reduction in deuterium was linked to improved metabolic processes, enhanced function of the nonspecific immune system, and increased body weight after 42 days in rats that adapted to the changed D/H ratio.
Article Abstract
The effect of isotope exchange reactions (deuterium/protium, D/H) on morphofunctional indices and the state of the antioxidant blood system in rats was studied under physiological conditions and during experimental chronic endotoxicosis of hepatorenal genesis. It was demonstrated that introduction of water with a decreased content of deuterium in the food rations of rats results in a decrease in its concentration in the blood plasma by 32-36% (to 98-106 ppm) and in lyophilized liver, kidney, and heart tissues by 13-17% (to 123-128 ppm). It was noted that it is accompanied by correction of metabolic processes, an increase in the functional activity of nonspecific protection system, and an increase in the body weight growth by the 42nd day in the group of animals that passed (for 14 days) the stage of preliminary adaptation with a change in the D/H ratio in the organism.
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