AI Article Synopsis
- * Methods: Researchers analyzed genetic data from 1,038 people, including a specific group of 127 individuals from Brazil, looking at allele distribution and similarities to other populations.
- * Results: The findings revealed that 37% of the population carried at least three harmful genetic variations, and 38.6% had one harmful variation in homozygous form, suggesting the need for genetic testing before treatment.
Article Abstract
Aim: To investigate polymorphisms that are probable indicators of response variability during cancer treatment with 5-fluorouracil (rs16430, rs2279198, rs1801159 and rs17878362).
Materials And Methods: We investigated 1,038 individuals regarding allele distribution from different populations, out of which we genotyped 127 individuals from a Brazilian admixed population. Similarity analyses with parental populations were performed. Prevalence of potentially deleterious alleles was also evaluated.
Results: Thirty-seven percent of the population had at least three potentially deleterious alleles and 38.6% had at least one potentially deleterious allele in homozygosis.
Conclusion: Potentially deleterious alleles are present under diverse frequencies in different populations. Therefore, genotyping prior to 5-fluorouracil administration should be recommended.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!