AI Article Synopsis
- Curcumin is a natural compound that could help prevent a type of throat cancer called HNSCC, but it usually doesn't get absorbed well when taken in pills.
- Researchers tested a new form of curcumin that can be absorbed better in the body and found higher levels of it in healthy people and cancer patients.
- The new curcumin method also showed that certain growth factors and signals in the body decreased in cancer patients, indicating it might have important effects on health.
Article Abstract
Background/aim: Curcumin is a promising nutraceutical for chemoprevention of head and neck squamous cell carcinoma (HNSCC). Capsular formulations of curcumin demonstrate low systemic bioavailability. We aimed to determine if curcumin levels were higher in healthy volunteers and cancer patients with microgranular curcumin that allows for transmucosal absorption and identify a consistent biomarker.
Patients And Methods: Eight healthy volunteers and 15 HNSCC patients completed the trials. Serum levels of curcumin were measured by HPLC. Biological activity of curcumin was assessed with Multiplex Immunoassay and immunohistochemistry.
Results: We achieved higher serum levels of curcumin compared to trials using capsular formulation. In cancer patients a significant decrease in expression of fibroblast growth factor-2 (FGF-2) in post-biopsy samples and decreased serum levels of FGF-2, granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin-17 (IL-17) (p<0.05) was observed.
Conclusion: Transmucosal administration of microgranular curcumin leads to enhanced curcumin bioavailability that is associated with significant biological effects.
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