AI Article Synopsis
- The study aimed to determine the relationship between resistin levels in early pregnancy and insulin resistance or preeclampsia (PE).
- Involving 285 normal pregnancies and 123 PE cases, researchers found that resistin levels negatively correlated with the severity of PE but showed no link to insulin resistance or other measured factors.
- The findings suggest that lower resistin levels are associated with severe cases of PE in the first trimester, indicating that inflammation and insulin sensitivity do not account for this reduction.
Article Abstract
Objective: To examine whether resistin levels in first trimester maternal serum are associated with insulin resistance or preeclampsia (PE).
Methods: A case-control study of maternal serum resistin concentration conducted using 285 normal pregnancies and 123 PE pregnancies matched for gestational age, parity and maternal age. Samples were taken in gestational weeks 10-13.
Results: There was a negative correlation between resistin and clinical severity of PE, but no correlation with IS, TNF-α, body mass index, birth weight and pregnancy length.
Conclusions: Resistin is reduced in first trimester of PE pregnancies, particularly in severe PE. Inflammation and IS cannot explain this phenomenon.
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| http://dx.doi.org/10.3109/10641955.2014.913615 | DOI Listing |
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