With the use of high-resolution MR imaging techniques, we have increasingly observed anomalies of the hypothalamus characterized by a band of tissue spanning the third ventricle between the hypothalami, often without associated clinical sequelae. Historically, hypothalamic anomalies are highly associated with symptoms referable to a hypothalamic hamartoma, midline congenital disorder, hypothalamic-pituitary dysfunction, or seizures, with very few asymptomatic patients reported. The interhypothalamic tissue described in our cohort was observed incidentally through the routine acquisition of high-resolution T1WI. No referable symptoms were identified in most of the study group. In the appropriate patient population in which associated symptoms are absent, the described hypothalamic anomalies may be incidental and should not be misdiagnosed as hypothalamic hamartomas.
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http://dx.doi.org/10.3174/ajnr.A4602 | DOI Listing |
Heliyon
February 2025
Environmental Science and Technology Research Center, Department of Environmental Health Engineering, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Per- and Poly-fluoroalkyl substances (PFASs) are among the substances that have been widely employed across the world due to their distinct features. These chemicals' great stability in the environment and capacity to be released from consumer goods have demonstrated their existence in all matrices. Additionally, the world's attention has been drawn to these substances' direct relation to human health in recent years.
View Article and Find Full Text PDFMol Neurobiol
March 2025
Department of Anatomy, Chonnam National University Medical School, Hwasun, 58128, Jeollanam-Do, Republic of Korea.
Metabolic syndrome, with a high global incidence, is characterized by central obesity, elevated fasting blood glucose, high blood pressure, and abnormal lipid levels, including reduced high-density lipoprotein cholesterol and elevated triglycerides. These metabolic dysfunctions can lead to neurotransmitter alterations and dysregulation of the hypothalamic-pituitary-adrenal axis. These changes, in turn, contribute to mental disorders such as depression and anxiety.
View Article and Find Full Text PDFWernicke's encephalopathy (WE) is an acute neurological disorder secondary to thiamine deficiency (vitamin B1). Treatment should be started as early as possible to prevent serious complications. Typical magnetic resonance imaging (MRI) findings of WE can be seen as symmetrical signal abnormalities in the periventricular regions of the thalamus, hypothalamus, mammillary bodies, periaqueductal region, and floor of the fourth ventricle.
View Article and Find Full Text PDFComput Biol Med
February 2025
Department of Translational Biomedicine and Neuroscience (DiBraiN), University of Bari Aldo Moro, Bari, Italy; Center for Neurodegenerative Diseases and the Aging Brain, University of Bari Aldo Moro at Pia Fondazione "Card. G. Panico", Tricase, Italy. Electronic address:
Objective: The aim of this study is to analyze hypothalamic changes and clinical/metabolic correlates with a radiomic approach in Amyotrophic Lateral Sclerosis (ALS).
Methods: We retrospectively identified 54 sporadic ALS patients and 53 matched controls. We compared radiomics features over hypothalamic subunits in T1-weighted.
Ultrasound Int Open
December 2024
Department of Gynaecology, Obstretrics and Gyn. Endocrinology, Kepler University Hospital, Linz, Austria.
To detect sonographic abnormalities of the supratentorial structures of the brain - future cavum septum pellucidum, cavum velum interpositum, third ventricle, ganglionic eminence and thalamus/hypothalamus - in fetuses with a crown-rump length of 45-84 mm in high-risk pregnancies. This study presents the retrospective analysis of transvaginally recorded 3D volumes of the fetal brain of 64 fetuses whose mothers consulted our ambulatory department for fetomaternal medicine for organic and/or genetic changes of their fetuses at GW 12-14. For this study we selected fetuses with 3D volume blocks of the fetal brain at best sonographic quality enabling detailed analysis and measurement of the supratentorial brain structures to correlate the results with the results of genetic analysis, ultrasound controls in later weeks of pregnancy, and fetal outcome.
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