AI Article Synopsis
- Lung function measurements are essential for diagnosing chronic obstructive pulmonary disease (COPD) and were studied through a genome-wide association analysis in over 38,000 individuals of European ancestry.
- Researchers identified 14 new genetic loci associated with lung function traits like forced expiratory volume (FEV1) and forced vital capacity (FVC), along with additional signals at known loci.
- These findings enhance our understanding of the genetic factors influencing lung function and related pulmonary diseases, potentially leading to new diagnostic and therapeutic approaches.
Article Abstract
Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10(-8)) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686825 | PMC |
| http://dx.doi.org/10.1038/ncomms9658 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!