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Body composition and physical performance of mountain bike athletes.
Sci Rep
January 2025
Postgraduate Program in Food and Nutrition at the Federal University of Piauí (PPGAN/UFPI), Teresina, Piauí, Brazil.
Body composition is a determining factor in the physical performance of cyclists, directly influencing efficiency and power during competitions. Understanding these aspects can help optimize training and maximize results. This study aimed to analyze the influence of body composition on physical performance in mountain bike athletes.
View Article and Find Full Text PDFGlobally, an estimated 2.1 billion malaria cases and 11.7 million malaria deaths were averted in the period 2000-2022.
View Article and Find Full Text PDFEndoplasmic reticulum stress in liver fibrosis: Mechanisms and therapeutic potential.
Biochim Biophys Acta Mol Basis Dis
January 2025
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, Hefei, China; School of Pharmacy, Anhui Medical University, Hefei, China; Institute for Liver Diseases of Anhui Medical University, Hefei, China. Electronic address:
This paper reviews the important role of endoplasmic reticulum stress in the patho mechanism of liver fibrosis and its potential as a potential target for the treatment of liver fibrosis. Liver fibrosis is the result of sustained inflammation and injury to the liver due to a variety of factors, triggering excessive deposition of extracellular matrix and fibrous scar formation, which in turn leads to loss of liver function and a variety of related complications. Endoplasmic reticulum stress is one of the characteristics of chronic liver disease and is closely related to the pathological process of chronic liver disease, including alcohol-related liver disease, viral hepatitis, and liver fibrosis.
View Article and Find Full Text PDFZDHHC2 promoted antimycobacterial responses by selective autophagic degradation of B-RAF and C-RAF in macrophages.
Sci Adv
January 2025
Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China.
S-Palmitoylation is a reversible post-translational modification involving saturated fatty acid palmitate-to-cysteine linkage in the protein, which guides many aspects of macrophage physiology in health and disease. However, the precise role and underlying mechanisms of palmitoylation in infection of macrophages remain elusive. Here, we found that infection induced the expression of zinc-finger DHHC domain-type palmitoyl-transferases (ZDHHCs), particularly ZDHHC2, in mouse macrophages.
View Article and Find Full Text PDFExosome's Implications in Age-Related Macular Degeneration.
Curr Eye Res
January 2025
Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA.
Purpose: This study aims to conduct a mini review of published literature concerning the role of exosomes in the field of ophthalmology, with a specific focus on Age-Related Macular Degeneration (AMD).
Methods: In this study, a comprehensive search was conducted using PubMed and Google Scholar to identify relevant publications. Additionally, trials submitted to clinicaltrials.
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