Background: In Italy, the nsLTP (Pru p 3) has been identified as the most frequent cause of food allergy and anaphylaxis. In order to estimate the risk assessment in peach allergy, we investigated the presence of correlations between the levels of sIgE to Pru p 3 with the severity of the clinical symptoms in two Pru p 3 positive populations from two different areas of Italy.
Methods: 133 consecutively Pru p 3 positive patients were recruited from South Italy, where the prevalence of PR-10 and profilin sensitization is low, and from North-East Italy, where the sensitization to pathogenesis related protein -10 (PR-10) and profilin is higher. Skin prick test (SPT) to peach extract and sIgE to peach panallergens were performed.
Results: All 133 patients were positive to SPT to peach extract and to sIgE to Pru p 3. The North-East population was simultaneously positive to Pru p 1 (42.8 %) and Pru p 4 (12.7 %), while no Southern patients were positive to PR-10 or to profilin. A significant difference in the levels of sIgE to Pru p 3 was found only in South Italy Pru p 3 + patients vs. asymptomatic patients (p = 0.01) and in mild reactions vs. severe reactions (p = 0.0008). In South Italy patients, it was also found a significant correlation between the severity of the clinical reaction and the levels of sIgE to Pru p 3 (p = 0.001).
Conclusion: Level of sIgE to Pru p 3 indicates the possibility of development a severe food allergic reaction. Pru p 3 positive patients from different geographical areas and with different co-sensitizations to Pru p 1 and/or Pru p 4 could have a different risk assessment in peach allergy.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667484 | PMC |
| http://dx.doi.org/10.1186/s12948-015-0035-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Peach component-specific IgE measurement helps to differentiate between local and systemic reactions in peach-allergic Japanese patients.
Allergol Int
December 2024
Department of Pediatrics, Dokkyo Medical University, Tochigi, Japan. Electronic address:
Background: Component-resolved diagnostics are used to diagnose food allergies. Currently, reports on sensitization profiles using peach-allergen components in a multicenter setting are lacking. In this study, sensitization profiling of peach allergy was performed to evaluate the clinical utility of each component specific-immunoglobulin E antibody (sIgE ab) test.
View Article and Find Full Text PDFClinical and sensitization profile in peach allergy due to LTP sensitization.
Front Allergy
December 2024
Gregorio Marañón Health Research Institute, Allergy Department, Gregorio Marañón General University Hospital, Madrid, Spain.
Background: Lipid transfer proteins (LTP) are associated with a wide range of severity of allergic reactions. However, the risk factors associated with this severity are not fully understood.
Objectives: To describe the clinical characteristics of peach-allergic patients due to LTP sensitization and analyze the relationship between the severity of the reactions and patients' sensitization profiles.
Pollen-Food Allergy Syndrome: From Food Avoidance to Deciphering the Potential Cross-Reactivity between Pru p 3 and Ole e 7.
Nutrients
August 2024
Department of Immunology and Allergy, Reina Sofía University Hospital, 14004 Córdoba, Spain.
Background: Cross-reactivity between nonspecific lipid transfer proteins could cause anaphylaxis, further influencing food avoidance and nutrient deficiencies. The one affecting olive pollen (Ole e 7) and peach (Pru p 3) may underlie a variety of pollen-food syndromes, though a deep molecular analysis is necessary.
Methods: Three Ole e 7-monosensitised patients (MON_OLE), three Pru p 3-monosensitised patients (MON_PRU) and three bisensitised patients (BI) were selected.
Pru p 3-specific IgE affinity is crucial in severe peach-allergy patients.
World Allergy Organ J
June 2024
Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
Article Synopsis
- Peach allergy is common, but the role of specific antibodies in patients is not well understood, especially factors beyond just Pru p 3-sIgE levels that could lead to severe symptoms.
- The study compared peach component-specific antibodies (IgE, IgG1, IgG4) in peach-allergy patients and healthy controls to examine differences in immune responses and severity of symptoms.
- Results indicated that Pru p 3 is the main allergen, with higher levels and affinity of Pru p 3-sIgE being linked to more severe reactions, particularly in those with peach-induced anaphylaxis.
Sensitisation to peach allergen Pru p 7 is associated with severe clinical symptoms in a Spanish population.
Pediatr Allergy Immunol
September 2023
Department of Allergy, Institute for Health Research (IdiPAZ), La Paz University Hospital, Madrid, Spain.
Article Synopsis
- Pru p 7 is a significant allergen linked to severe peach allergies, often associated with sensitisation to cypress pollen, particularly in pediatric patients in Madrid.
- The study included 92 patients who experienced IgE-mediated symptoms after consuming peaches, with 16.3% showing sensitisation to Pru p 7, which correlated with more severe allergic reactions.
- Findings indicated that sensitisation to Pru p 7 was more common in patients experiencing upper airway symptoms and anaphylaxis, along with increased likelihood of a positive oral food challenge.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!