AI Article Synopsis
- * Researchers analyzed clinical data from 179 patients, finding that those with high RDW (≥15%) had significantly shorter disease-free survival (DFS) and overall survival (OS) compared to those with lower RDW (<15%).
- * The findings indicate that high RDW at diagnosis is an independent predictor of poorer survival outcomes in esophageal cancer patients, suggesting it could be a useful biomarker for prognosis.
Article Abstract
Background: The red cell distribution width (RDW) has also been reported to reliably reflect the inflammation and nutrition status and predict the prognosis across several types of cancer, however, the prognostic value of RDW in esophageal carcinoma has seldom been studied.
Methods: A retrospective study was performed to assess the prognostic value of RDW in patients with esophageal carcinoma by the Kaplan-Meier analysis and multivariate Cox regression proportional hazard model. All enrolled patients were divided into high RDW group (≧15%) and low RDW group (<15%) according to the detected RDW values.
Results: Clinical and laboratory data from a total of 179 patients with esophageal carcinoma were retrieved. With a median follow-up of 21months, the high RDW group exhibited a shorter disease-free survival (DFS) (p<0.001) and an unfavorable overall survival (OS) (p<0.001) in the univariate analysis. The multivariate analysis revealed that elevated RDW at diagnosis was an independent prognostic factor for shorter PFS (p=0.043, HR=1.907, 95% CI=1.020-3.565) and poor OS (p=0.042, HR=1.895, 95% CI=1.023-3.508) after adjustment with other cancer-related prognostic factors.
Conclusion: The present study suggests that elevated preoperative RDW(≧15%) at the diagnosis may independently predict poorer disease-free and overall survival among patients with esophageal carcinoma.
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| http://dx.doi.org/10.1016/j.cca.2015.11.025 | DOI Listing |
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