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| http://dx.doi.org/10.7448/IAS.18.1.20814 | DOI Listing |
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Membrane-bound receptor for advanced glycation end products (RAGE) is a stable biomarker of low-quality sperm.
Hum Reprod Open
November 2024
School of Biochemistry & Immunology, Trinity College Dublin, Dublin, Ireland.
Study Question: Does receptor for advanced glycation end products (RAGE) on the surface membrane of the sperm cell function as a biomarker of low-quality sperm?
Summary Answer: Membrane-bound RAGE at a cellular level directly correlates with low sperm motility, high cell permeability, decreased mitochondrial function, DNA fragmentation, and higher levels of apoptosis.
What Is Known Already: RAGE has previously been measured by ELISA in low-quality sperm in diabetic men and has been shown to correlate with DNA fragmentation (terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL) assay).
Study Design Size Duration: Semen samples were recovered from 60 non-obese, non-diabetic and non-smoking subjects, washed with fresh media, and analysed directly or purified further by differential gradient centrifugation (DGC) or fractionated by direct swim-up before being analysed for sperm motility and molecular health parameters, including cell membrane permeability, cell death, mitochondrial membrane potential, DNA fragmentation, and RAGE protein expression.
Research trends on parasocial interactions and relationships with media characters. A review of 281 English and German-language studies from 2016 to 2020.
Front Psychol
September 2024
Department of Media and Business Communication, Institute Human-Computer-Media, University of Würzburg, Würzburg, Germany.
Parasocial phenomena are among the most popular and best-researched topics in media reception and effects research. The research can now look back on a history of over 65 years and has experienced another significant boom in recent years. Between 2016 and 2020, more studies were published than in the entire previous 60 years.
View Article and Find Full Text PDFPathological Assessment of Men with Grade Group 2 Prostate Cancer.
World J Mens Health
August 2024
Department of Urology, Western Sydney Local District, Granville, NSW, Australia.
Article Synopsis
- - The study focuses on determining treatment strategies for men with Grade Group 2 localized prostate cancer, aiming to identify those at risk for disease progression and poor outcomes.
- - It analyzed data from 243 patients who underwent radical prostatectomy, revealing that factors like PSA levels and PI-RADS scores are significant indicators of disease upgrading.
- - The findings suggest employing Strategy 8, which combines certain clinical indicators, to better identify patients at highest risk, highlighting the need for further validation of this approach in clinical settings.
Cribriform pattern 4/intraductal carcinoma of the prostate and persistent prostate-specific antigen after radical prostatectomy.
BJUI Compass
July 2024
Department of Nephro-Urologic Surgery and Andrology, Graduate School of Medicine Mie University Tsu Japan.
Article Synopsis
- - The study aims to determine how the presence of cribriform pattern 4 carcinoma/intraductal carcinoma of the prostate (CC/IDCP) affects the likelihood of having persistent prostate-specific antigen (PSA) levels after robot-assisted radical prostatectomy (RARP) in men with localized prostate cancer.
- - Researchers analyzed data from 730 patients who underwent RARP between 2015 and 2021, excluding those with metastasis or previous cancer treatments, to assess the correlation between CC/IDCP and persistent PSA levels, defined as PSA ≥0.2 ng/mL one month after surgery.
- - The findings showed 6.3% of patients had persistent PSA levels, with CC/IDCP identified
Clinical Analysis of Y Chromosome Microdeletions and Chromosomal Aberrations in 1596 Male Infertility Patients of the Zhuang Ethnic Group in Guangxi.
Reprod Sci
October 2024
Department of Medical Laboratory, The Third Affiliated Hospital of Guangxi Medical University/The Second Nanning People's Hospital, Nanning, 530031, Guangxi, China.
The long arm of the Y chromosome (Yq) contains many amplified and palindromic sequences that are prone to self-reorganization during spermatogenesis, and tiny submicroscopic segmental deletions in the proximal Yq are called Y chromosome microdeletions (YCM). A retrospective study was conducted on male infertility patients of Zhuang ethnicity who presented at Reproductive Medical Center of Nanning between January 2015 and May 2023. Seminal fluid was collected for standard examination.
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