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| http://dx.doi.org/10.1111/bcp.12856 | DOI Listing |
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Risk of hospital inpatient opioid overdose (RHINOO): a review of factors impacting naloxone administration in patients receiving opioids.
Eur J Clin Pharmacol
January 2025
Department of the Acute Pain Service, St. Luke's University Health Network, 801 Ostrum St, Bethlehem, PA, 18015, USA.
Purpose: Opioid medications remain a common treatment for acute pain in hospitalized patients. This study aims to identify factors contributing to opioid overdose in the inpatient population, addressing the gap in data on which patients are at higher risk for opioid-related adverse events in the hospital setting.
Methods: A retrospective chart review of inpatients receiving at least one opioid medication was performed at a large academic medical center from January 1, 2022, through December 31, 2022.
Impact of Enhanced Recovery After Surgery protocol with multimodal anesthesia on perioperative outcomes after open abdominal aortic aneurysm repair.
J Vasc Surg
December 2024
Department of Surgery, Florida Atlantic University College of Medicine, Boca Raton, FL; Baptist Health South Florida at Boca Raton Regional Hospital, Boca Raton, FL. Electronic address:
Objective: Enhanced Recovery After Surgery (ERAS) clinical pathways have demonstrated improved perioperative outcomes after major surgery. However, its adoption within vascular surgery has been limited. In this study, we examined the impact of an ERAS protocol with multimodal anesthesia on open abdominal aortic aneurysm (AAA) repair by comparing early outcomes before and after its implementation.
View Article and Find Full Text PDFPerioperative methadone compared to placebo in elderly hip fracture patients: a study protocol for a randomized controlled trial (MetaHip trial).
Trials
December 2024
Department of Orthopedics, University Hospital of Southern Denmark, Kresten Philipsensvej 15, Aabenraa, 6200, Denmark.
Background: Hip fractures are a source of severe pain among the elderly population and pose challenges due to limited analgesic tolerance. Perioperative methadone has shown promise in our pilot study suggesting a safe dose of 0.10 mg/kg, prompting further investigation into its benefits for elderly hip fracture patients.
View Article and Find Full Text PDFOccurrence of Opioid-Related Neurocognitive Symptoms Associated With Long-term Opioid Therapy.
Clin J Pain
February 2025
Department of Public Health and Center for Health Statistics, University of Massachusetts Lowell, Lowell, MA.
Objective: Neurocognitive symptoms (NCSs) may be early indicators of opioid-related harm. We aimed to evaluate the incidence and potential attribution of opioid-related NCS among patients on long-term opioid therapy (LOT) by using natural language processing to extract data from the electronic health records within the Veterans Health Administration.
Methods: We conducted a retrospective cohort study of patients prescribed LOT in 2018.
The Effects of Low-Dose Morphine on Sleep and Breathlessness in COPD: A Randomized Trial.
Chest
December 2024
Flinders Health and Medical Research Institute/Adelaide Institute for Sleep Health, Flinders University, Adelaide, Australia.
Background: Low-dose morphine may be prescribed to reduce chronic breathlessness in COPD. Subjective findings suggest morphine may influence breathlessness through sleep-related mechanisms. However, concerns exist regarding opioid safety in COPD.
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