Topiramate (TPM) is an antiepileptic drug able to play a role in both neurological and psychiatric disorders. TPM facilitates gamma-aminobutyric acid (GABA) transmission and inhibits glutamatergic transmission (i.e. AMPA/kainate receptors). Several studies reported that the modulation of GABAergic and glutamatergic synaptic transmission may reduce cocaine reinforcement. Therefore, TPM could be used in the management of cocaine dependence.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759320 | PMC |
| http://dx.doi.org/10.2174/1570159x13666150729222643 | DOI Listing |
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