Coal in India is extracted generally by semi-mechanized and mechanized underground mining methods. The Bord and Pillar (B & P) mining method still continues to be popular where deployment of manual miners is more than that of other mining methods. The study is conducted at haulage based mine of Eastern Coalfields of West Bengal. Underground miners confront with a lot of hazards like extreme hostile environment, awkward working posture, dust, noise as well as low luminosity. It is difficult to delay the onset of fatigue. In order to study the physiological responses of trammers, various parameters like working heart rates, net cardiac cost and relative cardiac cost including recovery heart rate patterns are recorded during their work at site. Workload classification of trammers has been done following various scales of heaviness. The effect of environment on the physiological responses has been observed and suitable recommendations are made. The work tasks are bound to induce musculoskeletal problems and those problems could be better managed through rationalizing the work-rest scheduling.
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Proc Natl Acad Sci U S A
February 2025
Molecular Ecology and Evolution Group, School of Environmental and Natural Sciences, Bangor University, Bangor LL57 2UW, United Kingdom.
Phenotypic plasticity may pave the way for rapid adaptation to newly encountered environments. Although it is often contested, there is growing evidence that initial plastic responses of ancestral populations to new environmental cues may promote subsequent adaptation. However, we do not know whether plasticity to cues present in the ancestral habitat (past-cue plasticity) can facilitate adaptation to novel cues.
View Article and Find Full Text PDFPLoS Biol
January 2025
Department of Biology, University of Fribourg, Fribourg, Switzerland.
Elife
January 2025
Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, United States.
Sensory experience during developmental critical periods has lifelong consequences for circuit function and behavior, but the molecular and cellular mechanisms through which experience causes these changes are not well understood. The antennal lobe houses synapses between olfactory sensory neurons (OSNs) and downstream projection neurons (PNs) in stereotyped glomeruli. Many glomeruli exhibit structural plasticity in response to early-life odor exposure, indicating a general sensitivity of the fly olfactory circuitry to early sensory experience.
View Article and Find Full Text PDFInflammopharmacology
January 2025
Neuropharmacology Division, Department of Pharmacology, ISF College of Pharmacy, Moga, 142001, Punjab, India.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-β plaques and tau tangles, leading to cognitive decline and dementia. Insulin-like Growth Factor-1 (IGF-1) is similar in structure to insulin and is crucial for cell growth, differentiation, and regulating oxidative stress, synaptic plasticity, and mitochondrial function. IGF-1 exerts its physiological effects by binding to the IGF-1 receptor (IGF-1R) and activating PI3K/Akt pathway.
View Article and Find Full Text PDFAdv Biotechnol (Singap)
April 2024
CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China.
In response to the changing intertidal environment, intertidal macroalgae have evolved complicated Ci utilization mechanisms. However, our knowledge regarding the CO concentrating mechanism (CCM) of macroalgae is limited. Carbonic anhydrase (CA), a key component of CCM, plays essential roles in many physiological reactions in various organisms.
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