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A Cordial Introduction to Double Scaled SYK.
Rep Prog Phys
January 2025
SISSA, via Bonomea 265, 34136 Trieste, Trieste, 34136, ITALY.
We review recent progress regarding the double scaled Sachdev-Ye-Kitaev model and other p-local quantum mechanical random Hamiltonians. These models exhibit an expansion using chord diagrams, which can be solved by combinatorial methods. We describe exact results in these models, including their spectrum, correlation functions, and Lyapunov exponent.
View Article and Find Full Text PDFThe canine blood-brain barrier in health and disease: focus on brain protection.
Vet Q
December 2025
Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.
This review examines the role of the canine blood-brain barrier (BBB) in health and disease, focusing on the impact of the multidrug resistance (MDR) transporter P-glycoprotein (P-gp) encoded by the gene. The BBB is critical in maintaining central nervous system homeostasis and brain protection against xenobiotics and environmental drugs that may be circulating in the blood stream. We revise key anatomical, histological and functional aspects of the canine BBB and examine the role of the gene mutation in specific dog breeds that exhibit reduced P-gp activity and disrupted drug brain pharmacokinetics.
View Article and Find Full Text PDFUnlabelled: Policy Points A redirection of measurement in health care from a narrow focus on diseases and care processes towards assessing whole person health, as perceived by the person themself, may provide a galvanizing view of how health care can best meet the needs of people and help patients feel heard, seen, and understood by their care team. This review identifies key tensions to navigate as well as four overarching categories of whole person health for consideration in developing an instrument optimized for clinical practice. The categories (body and mind, relationships, living environment and finances, and engagement in daily life) include nine constituent domains.
View Article and Find Full Text PDFAn Anticancer Bioactive Peptide Combined with Oxaliplatin Inhibited Gastric Cancer Cells and .
Curr Protein Pept Sci
January 2025
Key Laboratory of Medical Cell Biology in Inner Mongolia, Clinical Medical Research Center, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia,010050, China.
Background: Gastric cancer has become one of the major diseases threatening human health. This study aimed to investigate the mechanism of an anticancer bioactive peptide (ACBP) combined with oxaliplatin (OXA) on MKN-45, SGC7901, and NCI-N87 differentiated human gastric cancer cells and GES-1 immortalized human gastric mucosal epithelial cells. The therapeutic effect and action mechanism of short-term intermittent ACBP combined with OXA on nude mice with human gastric cancer were also investigated.
View Article and Find Full Text PDFDesigning dicationic organic salts and ionic liquids exhibiting high fluorescence in the solid state.
J Ion Liq
December 2024
Department of Chemistry and Biochemistry, University of Nevada Las Vegas, 4505 S. Maryland Parkway, Box 454003, Las Vegas, NV 89154, United States.
Dicationic ionic liquids (DILs) are emerging as a powerful, next-generation approach to designing applied ILs because of their superior physicochemical properties as well as their diverse complexity and tunability for task specific applications. DILs are scarce in the literature compared to monocationic ILs (MILs), and one of their main issues is their expected tendency to possess higher melting temperatures. A series of 1,4-bis[2-(4-pyridyl)ethenyl] benzene and 1,4-bis[2-(2-pyridyl)ethenyl]benzene quaternary salts (Q-BPEBs) with different counterions (bromide, tosylate, and triflimide) and carbon chain lengths (C, C, and C) have been synthesized for their potential as DILs with strong photoluminescent properties in the solid state.
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