AI Article Synopsis
- Data from 934 preterm deliveries across 11 Italian centers were analyzed for the years 1980, 1985, and 1986, focusing on respiratory distress syndrome (RDS) prevention.
- Corticosteroids were the main treatment but their usage decreased from 94% in 1980 to 74% in 1986, with only a small percentage of cases using a combination of substances.
- Despite attempts at pharmacological prevention in many cases, the incidence of RDS was not significantly different between treated and untreated groups; key factors influencing RDS were gestational age, birth weight, and Apgar score.
Article Abstract
Obstetric and neonatal data were collected on 934 preterm deliveries in 11 Italian centres in 1980, 1985 and 1986. Therapeutic regimens for prevention of respiratory distress syndrome (RDS) were applied in 42% of the cases in 1980, 32% in 1985 and 42% in 1986. Prevention was made in most cases with corticosteroids, although their use fell progressively from 94% in 1980 to 74% in 1986. A combination of two substances was used in a percentage of cases varying from 5 to 10% in all three years. In 903 non-malformed infants, the overall incidence of RDS was not significantly different in cases in which pharmacological prevention was attempted compared with cases without prevention. The only factors significantly affecting the incidence of RDS were gestational age, birth weight and Apgar score.
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