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Correlation between VEGFR2 rs2071559 polymorphism and glioma risk among Chinese population. | LitMetric

Correlation between VEGFR2 rs2071559 polymorphism and glioma risk among Chinese population.

Int J Clin Exp Med

Department of Neurosurgery, Wuhan General Hospital of Guangzhou Command, Hubei Key Laboratory of Central Nervous System Tumor and Intervention Wuhan 430070, China.

Published: December 2015

AI Article Synopsis

Article Abstract

Objective: We investigated the correlation between vascular endothelial growth factor 2 (VEGFR2) polymorphism and glioma risk among Chinese population.

Method: Case-control study design was adopted, and blood samples and clinical data of 250 glioma cases and 260 control subjects were collected. Epidemiological questionnaire survey was performed, and DNA extraction, concentration normalization and packaging were carried out using Qiagen Blood Kit. TaqMan method was performed for VEGFR2 rs2071559 genotyping.

Results: C allele of VEGFR2 rs2071559 genotype was the susceptibility allele contributing to the risk of glioma (OR=1.813, 95% CI: 1.393-2.359, P=0.014). CC genotypes of VEGFR2 rs2071559 were associated with increased risk of glioma (OR=2.068, 95% CI: 1.164-3.674, P=0.014; Adjusted OR=1.883, 95% CI: 1.430~3.013, P=0.018).

Conclusion: CC genotypes of VEGFR2 rs2071559 were associated with glioma risk among Chinese population. However, the role of VEGFR2 rs2071559 polymorphism in glioma susceptibility remains to be further clarified.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659099PMC

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