Prognostic role of microRNA-210 in various carcinomas: a meta-analysis.

Background: MicroRNA (miRNA) expressive alterations are associated with cancer and have potential diagnostic and prognostic values in various malignancies. Here, we summarize the global predictive role of miR-210 expression for survival in patients with a variety of carcinomas.

Methods: Eligible studies were identified through multiple search strategies. Data were assembled from studies investigating the relationship between miR-210 expression and survival in cancer patients. Hazard ratio (HR) was used as the common measure of association across studies: relative risk (RR) was considered equivalent to HR. Combined hazard ratios (HRs) of miR-210 for outcome were analyzed.

Results: A total of 10 studies dealing with various carcinomas were included for this global meta-analysis. For overall survival (OS), the pooled hazard ratio (HR) of higher miR-210 expression in cancerous tissue was 2.41 (95% CI: 1.31-4.44), which could significantly predict poorer survival in general carcinomas. For distant-free, relapse-free or progressive-free survival, elevated miR-210 was also a significant predictor, with a pooled HR of 2.84 (95% CI: 2.10-3.83). Importantly, subgroup analysis suggested that higher expression of miR-210 correlated with worse OS in breast cancer: HR 4.34, 95% CI: 1.63-11.55.

Conclusions: Our findings reveal that miR-210 detection has a prognostic value in patients with cancer, especially in breast cancer.