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A case of cryptococcoma in an immunocompetent man with polysubstance use.
IDCases
July 2023
Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA.
Cryptococcus most commonly affects the pulmonary and central nervous systems in patients who are immunocompromised. It is most likely to present as meningitis. However, it can affect immunocompetent patients in the cerebral parenchyma.
View Article and Find Full Text PDFEpidemiology, management and outcomes of Cryptococcus gattii infections: A 22-year cohort.
PLoS Negl Trop Dis
March 2023
Department of Infectious Diseases, Royal Darwin Hospital, Darwin, Australia.
Background: Cryptococcus gattii is a globally endemic pathogen causing disease in apparently immune-competent hosts. We describe a 22-year cohort study from Australia's Northern Territory to evaluate trends in epidemiology and management, and outcome predictors.
Methods: A retrospective cohort study of all C.
Pulmonary Cryptococcosis.
J Fungi (Basel)
October 2022
Centre for Infectious Diseases & Microbiology Laboratory Services, New South Wales Health Pathology-Institute of Clinical Pathology & Medical Research, Westmead Hospital, Westmead, NSW 2145, Australia.
Pulmonary cryptococcosis describes an invasive lung mycosis caused by or complex. It is often a high-consequence disease in both immunocompromised and immunocompetent populations, and may be misdiagnosed as pulmonary malignancy, leading to a delay in therapy. Epidemiology follows that of cryptococcal meningoencephalitis, with infection more common in certain geographic regions.
View Article and Find Full Text PDFComparison of features and outcomes between HIV-negative patients with Cryptococcus gattii meningitis and Cryptococcus neoformans meningitis in South China.
Mycoses
September 2022
Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Objectives: The objective of this study is to compare the epidemiologic, clinical, laboratory, and imaging features, and outcomes in patients with Cryptococcus gattii meningitis (CGM) and Cryptococcus neoformans meningitis (CNM).
Methods: We performed a retrospective study of HIV-negative patients with CGM and CNM (2015-2021) distinguished by metagenomic next-generation sequencing in cerebrospinal fluid in South China.
Results: A total of 81 patients (17 CGM, 64 CNM) were enrolled (72.
Rapidly enlarging pulmonary mass due to immune reconstitution inflammatory syndrome (IRIS) in an immunocompetent host with pulmonary .
BMJ Case Rep
March 2022
Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut, USA.
An immunocompetent man presented with disease manifesting as a large pulmonary mass (cryptococcoma). Despite an initial induction course of 4 weeks of liposomal amphotericin B (LAmB), followed by 8 weeks of fluconazole, the cryptococcoma enlarged in size. Ten days into a second course of induction therapy with LAmB and flucytosine, the cryptococcoma markedly increased in size with encroachment on critical vascular structures.
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