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Streamlined Vitamin D Metabolite Fingerprinting Analysis Using Isotope-Coded Multiplexing MS with Cost-Effective One-Pot Double Derivatization.
ACS Omega
December 2024
Department of Chemistry, Humboldt Universität zu Berlin, Brook-Taylor-Str. 2, Berlin 12489, Germany.
In this study, we extended a previously developed one-pot double derivatization reaction to establish the first routine isotope-coded multiplex derivatization for vitamin D and its metabolites for application in clinical environments, using commercial reagents, without the need for specialized reagents and advanced synthesis requirements. The original derivatization process consisted of using both a Cookson-type reagent and derivatization of hydroxyl groups. Initially, the analytes are derivatized by a Diels-Alder reaction using 4-phenyl-1,2,4-triazoline-3,5-dione (PTAD), followed by acetylation using acetic anhydride, catalyzed by 4-dimethylaminopyridine at room temperature.
View Article and Find Full Text PDFSynthesis of novel α-spinasterol derivatives and their inhibitory effects on CCL17 and CCL22 chemokine expression.
Steroids
December 2024
Department of Applied Chemistry, Global Center for Pharmaceutical Ingredient Materials, Kyung Hee University, 1732 Deogyeong-daero, Giheung-gu, Yongin-si, Gyeonggi-do 17104, Republic of Korea. Electronic address:
Natural α-spinasterol is well known for its various biological activities. In this study, we investigated the anti-inflammatory effects of newly synthesized α-spinasterol derivatives by tracking the expression of CCL17 and CCL22 chemokines, which serve as biomarkers for immune cell trafficking in skin inflammation. Initially, the 3-epimer of α-spinasterol, which results from inversion of stereochemistry at the C-3 position of α-spinasterol, was synthesized using the Mitsunobu reaction.
View Article and Find Full Text PDFAdvances in the biosynthesis of D-allulose.
World J Microbiol Biotechnol
November 2024
School of Pharmaceutical Sciences and Food Engineering, Liaocheng University, Liaocheng, China.
Article Synopsis
- * There are two main ways to produce D-allulose: chemical synthesis, which can create unwanted byproducts, and biosynthesis, which uses enzymes to convert starch or glycerol into D-allulose more efficiently.
- * The article reviews recent research on biosynthesis, highlighting the enzymes used, their properties, and the potential for improved production methods for D-allulose.
Low-calorie d-allulose as a sucrose alternative modulates the physicochemical properties and volatile profile of sponge cake.
J Food Sci
October 2024
Department of Food Science and Technology, National University of Singapore, Singapore, Singapore.
d-Allulose, a C-3 epimer of d-fructose, is a rare sugar with ∼70% of the sweetness of sucrose but a caloric content of only 0.4 kcal/g. Due to its low-calorie nature, d-allulose has garnered increasing interest in the food industry.
View Article and Find Full Text PDFMetabolic Profiling of Rat Kidney Tissue Following Administration of D-Allulose.
J Appl Glycosci (1999)
August 2024
1 Research and Development, Matsutani Chemical Industry Co., Ltd.
D-Allulose (D-psicose) is a rare sugar and a C-3 epimer of D-fructose. D-Allulose has been reported to have several health benefits via its alteration of both glucose and lipid metabolism. It was previously reported that D-allulose alters the hepatic metabolomic profile.
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