Reversible Fluoxetine-Induced Hyperthyroidism: A Case Report.

Clin Neuropharmacol

*Department of Mental Health, The First Affiliated Hospital, Zhejiang UniversitySchool of Medicine, Hangzhou, China; †MRI Unit, Epidemiology Division, Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY; ‡Institute of the Developing Mind, Children's Hospital Los Angeles, Keck School of Medicine at the University of Southern California, Los Angeles, CA; §The Key Laboratory of Mental Disorder's Management in Zhejiang Province; and ∥Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Published: October 2016

Background: Selective serotonin reuptake inhibitors (SSRIs) are typically used as antidepressants. Clinically significant SSRI-induced thyroid dysfunction is rare.

Case: We report a case of hyperthyroidism induced by fluoxetine in a female patient with major depressive disorder. Her thyroid profiles indicated hyperthyroidism after a 10-week treatment with fluoxetine and were restored after discontinuation of fluoxetine and administration with venlafaxine. In the first year of follow-up, her thyroid functions as well as her depressive symptoms remained perfectly normal.

Conclusions: This case highlights the necessity of monitoring thyroid profiles during SSRI treatment.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714632PMC
http://dx.doi.org/10.1097/WNF.0000000000000116DOI Listing

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