Nocardia species are ubiquitous soil-borne organisms that most commonly cause invasive disease in patients with defective cell-mediated immunity. We report a case of recurrent Nocardia sepsis in a patient with sickle cell disease and chronic iron overload, who was undergoing high-dose infusions of deferoxamine through a central venous catheter.

Download full-text PDF

Source
http://dx.doi.org/10.1093/jpids/pit038DOI Listing

Publication Analysis

Top Keywords

recurrent nocardia
8
nocardia sepsis
8
sepsis patient
8
patient sickle
8
sickle cell
8
cell anemia
4
anemia receiving
4
receiving continuous
4
continuous deferoxamine
4
deferoxamine nocardia
4

Similar Publications

Article Synopsis
  • - A woman with colon adenocarcinoma developed necrotizing pneumonia and empyema shortly after chemotherapy, leading to the placement of a chest tube for fluid analysis.
  • - She underwent pleural decortication via video-assisted thoracoscopy and received treatment with trimethoprim-sulfamethoxazole and imipenem/cilastatin.
  • - After four weeks of treatment, she was discharged on oral trimethoprim-sulfamethoxazole with no recurrence during follow-up; the importance of antibiotic susceptibility testing and monitoring side effects was emphasized.
View Article and Find Full Text PDF

Background: Nocardiosis poses a diagnostic challenge due to its rarity in clinical practice, non-specific clinical symptoms and imaging features, and the limitations of traditional detection methods. () is rarely detected in clinical samples. Metagenomic next-generation sequencing (mNGS) offers significant advantages over traditional methods for rapid and accurate diagnosis of infectious diseases, especially for rare pathogens.

View Article and Find Full Text PDF

Musculoskeletal infections associated with species: a case series.

J Bone Jt Infect

September 2024

Division of Public Health, Infectious Diseases and Occupational Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

: is an uncommon pathogen that has been reported to infect musculoskeletal structures. However, studies are largely limited to case reports, and little is known regarding management and outcomes of these infections. : We performed a multicenter retrospective cohort study of adults with culture-confirmed musculoskeletal infections at three Mayo Clinic centers in Arizona, Florida, and Minnesota from November 2011 through April 2022.

View Article and Find Full Text PDF
Article Synopsis
  • Idiopathic CD4 lymphocytopenia (ICL) is an immunodeficiency syndrome with persistent low CD4 counts and increased risk of opportunistic infections, notably including nocardiosis, which is rarely reported in ICL patients.
  • A 46-year-old woman with a history of pulmonary nocardiosis and ICL presented with symptoms after four years, where tests confirmed the presence of Nocardia otitidiscaviarum.
  • The case highlights the need for regular follow-up and CD4 count monitoring in ICL patients to prevent infections and emphasizes the relevance of secondary prophylaxis therapy following initial treatment.
View Article and Find Full Text PDF

Challenging Case of Postoperative Endophthalmitis.

J Vitreoretin Dis

July 2024

Shri Bhagwan Mahavir Vitreoretinal Services, Chennai, Tamil Nadu, India.

To describe a case of postoperative endophthalmitis that proved to be challenging. A 64-year-old woman presented with a clinical picture of postoperative endophthalmitis, which was managed by vitrectomy with intraocular lens explantation. , sensitive to amikacin, cotrimoxazole (trimethoprim-sulfamethoxazole), and ciprofloxacin, was isolated in culture.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!