Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705903 | PMC |
| http://dx.doi.org/10.1038/bjc.2015.404 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Synthesis of bioisosteres of caffeic acid phenethyl ester: 1,3,4-oxadiazole derivatives containing a catechol fragment with anti-inflammatory activities in vitro and in vivo.
Bioorg Chem
January 2025
School of Pharmacy, Lanzhou University, Lanzhou 730000, China. Electronic address:
Aimed to enhance the anti-inflammatory activity of caffeic acid phenethyl ester (CAPE), the oxadiazole derivatives were synthesized by substituting its ester group. The structure-activity relationships revealed that the electron-withdrawing group in the phenethyl moiety enhanced anti-inflammatory activity. The order of activity potency was F ≥ CF > Cl > NO > CN.
View Article and Find Full Text PDFDexamethasone: a cheap and convenient way to alleviate subsequent stenosis after thermal injury on ureter.
Transl Androl Urol
November 2024
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Background: Ureteral thermal injury (UTI) occurs when the ureter is exposed to high temperatures during surgical procedures, leading to tissue damage and ureteral stricture. Dexamethasone (DEX) has been widely used to treat a variety of diseases for its anti-inflammatory and immunosuppressant effects. However, its role in treating UTI remains unclear.
View Article and Find Full Text PDFAnti-inflammatory effect of nestorone in a lipopolysaccharide-induced acute lung injury model through regulation of the TLR-4/Myd88/NF-κB signaling pathway.
Inflammopharmacology
December 2024
Department of Liver Surgery and Transplantation and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Progesterone plays a crucial and indispensable role in regulating immunity and attenuating inflammation. Nestorone (NES, segesterone acetate) is a steroidal progestin and a 19-norprogesterone derivative with no -CH group radical at the 6-position. Here, we showed that NES enhanced the viability of lipopolysaccharide (LPS)-stimulated THP-1 cell-derived macrophages, potently inhibiting both arms of the Toll-like receptor 4 (TLR-4) signaling cascade triggered by LPS, especially the TLR-4/MyD88/NF-κB pathway.
View Article and Find Full Text PDFCaffeic acid differentially modulates behavior and neurochemicals in chronic unpredictable mild stress and dexamethasone induced models of depression.
Pharmacol Biochem Behav
December 2024
SGT College of Pharmacy, SGT University, Gurugram, Haryana, India. Electronic address:
In the present study authors studied the effect of caffeic acid (CA) in chronic unpredictable mild stress (CUMS) and dexamethasone (DEXA) model of depression. CUMS (21 days) and DEXA (1.5 mg/kg × 21 days) was used for the induction of depression and anxiety related behavior.
View Article and Find Full Text PDFEleutheroside B alleviates oxidative stress and neuroinflammation by inhibiting the JAK2/STAT3 signaling pathway in a rat high altitude cerebral edema model.
Front Pharmacol
November 2024
Respiratory and Critical Care Medicine Center, Traditional Chinese Medicine Hospital of Meishan, Meishan, China.
Background: High altitude cerebral edema (HACE) is a condition where the central nervous system experiences severe impairment as a result of sudden oxygen deprivation at high elevations. At present, effective measures for preventing and treating this condition are still lacking. Eleutheroside B (EB), the primary natural active compound found in the , has demonstrated various biological functions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!