27 cases of neglected post-traumatic dislocations of the radius head were followed up for 30 years. 23 of the cases were neglected Monteggia fractures. The treatment varied over the years from no therapy to the presently used technique of cubital osteotomy associated with surgical repositioning to the radius dislocation. The follow-up results were analysed to determine: 1) whether surgical intervention was justified, as the function of the upper limb of these children was often perfectly good, 2) the type of surgery to use, 3) when such surgery should be done. The results form this study, and the review of 66 previously published cases indicate that surgery may be done on patients of any age, but preferably as early as possible, using precise surgical procedure, as these alone seem to guarantee a first class functional outcome, likely to improve on the pre-operative status of the patients.
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Curr Pharm Des
January 2025
University Institute of Pharma Sciences (UIPS), Chandigarh University, NH-95 Chandigarh Ludhiana Highway, Mohali Punjab, India.
Schizophrenia is a heterogeneous neuropsychological disorder characterized by three distinct sets of symptoms: positive, negative, and cognitive. It carries significant public health implications and is estimated to affect up to 1% of the population. Despite extensive research, the underlying mechanisms of schizophrenia are not entirely understood, and existing antipsychotic treatments have notable limitations.
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January 2025
Laboratory of Biotechnology and Molecular Biology, Health Sciences Center, State University of Ceara, Fortaleza 60714-903, Brazil.
Zika (ZIKV) and Dengue (DENV) viruses are clinically significant due to their severe neurological and hemorrhagic complications. Rapid diagnostics often rely on nonstructural proteins to generate specific antibodies. This study aimed to produce IgG antibodies from the recombinant ZIKV protein and plant-expressed NS2B protein for arbovirus detection in serum and urine samples.
View Article and Find Full Text PDFTravel Med Infect Dis
January 2025
Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Human schistosomiasis is a chronic neglected tropical disease caused by blood flukes of the genus Schistosoma, infecting 250 million people worldwide, mostly in sub-Saharan Africa. Recently, thousands of cases have been reported in immigrants to non-endemic countries, including Italy. Serological screening is recommended but so far, no accurate point-of-care (POC) and lab-free test is available.
View Article and Find Full Text PDFInt J Infect Dis
January 2025
FHI 360, Abidjan, Cote d'Ivoire. Electronic address:
Objectives: Lymphatic filariasis (LF) elimination efforts in Ghana have been ongoing since 2001, achieving substantial progress through mass drug administration (MDA). However, despite significant advances, LF transmission persists in certain areas. Some districts previously classified as non-endemic have reported lymphedema and hydrocele cases, raising concerns about LF endemicity.
View Article and Find Full Text PDFInt J Parasitol Drugs Drug Resist
January 2025
Department of Infectious Diseases, Unit of Foodborne and Neglected Parasitic Diseases, Istituto Superiore di Sanità, viale Regina Elena 299, Rome, Italy. Electronic address:
Giardia duodenalis is a widespread intestinal protozoan that affects mammals, including humans. Symptoms can range from being subclinical to causing severe abdominal pain and diarrhoea. Giardiasis often requires repeated treatment with synthetic drugs like metronidazole.
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