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Measurement properties of instruments to assess insight in psychosis: A systematic review protocol.
PLoS One
January 2025
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America.
Introduction: Insight in psychosis, defined as a patient's awareness and judgment of their mental illness, is a complex and evolving concept. Historically, the absence of insight was considered a defining characteristic of psychosis, but recent decades have seen the development of structured tools for its assessment. This systematic review aims to critically appraise the measurement properties of instruments used to assess insight in individuals with schizophrenia spectrum, bridging the gap between theoretical conceptualization and clinical practice.
View Article and Find Full Text PDFPlatform Selection for Patients Undergoing Transcatheter Aortic Valve Replacement: A Practical Approach.
Catheter Cardiovasc Interv
January 2025
IRCCS Pol. S. Donato, Milan, Italy.
Transfemoral transcatheter aortic valve Replacement (TAVR) has become the standard therapy for patients with severe aortic stenosis in patients over 75 years old in Europe or 65 years old in the United States, regardless of the surgical risk. Furthermore, iterations of existing transcatheter aortic valves (TAVs), as well as devices with novel concepts, have provided substantial improvements with respect to the limitations of previous-generation devices. Hence, treatment of a broader spectrum of patients has become feasible, and a sophisticated selection of the appropriate TAV tailored to patients' anatomy and comorbidities is now possible.
View Article and Find Full Text PDFVitrimeric electrolytes - overview and perspectives.
Chem Commun (Camb)
January 2025
Design of 3D-Printable Polymers Based on Regional Resources, Just Transition Center, Martin Luther University Halle-Wittenberg, 06099 Halle, Germany.
Lithium batteries, essential for consumer electronics, transportation and the energy sector, still require further improvement in performance, safety, and sustainability. Traditonal organic solvent-based electrolytes, widely used in current systems, pose significant safety risks and restrict the development of next generation devices. Vitrimers are materials with unique physical and chemical properties, which offer a promising alternative to overcome these limitations, finally reaching processability and recyclability of solid electrolytes.
View Article and Find Full Text PDFThere is increased interest in developing non-animal test systems for inhalation exposure safety assessments. However, defined methodologies are absent for predicting local respiratory effects from inhalation exposure to irritants. The current study introduces a concept for applying in vitro and in silico methods for inhalation exposure safety assessment.
View Article and Find Full Text PDFExploratory Studies on RNAi-Based Therapies Targeting Angiotensinogen in Hypertension: Scoping Review.
J Pers Med
December 2024
Medicine School, Pontifical Catholic University of Goiás, Goiânia 74605-010, Brazil.
Systemic arterial hypertension contributes to cardiovascular morbidity and mortality worldwide. Many patients cannot achieve optimal blood pressure (BP) control with traditional therapies, which often results in poor patient adherence and limited long-term efficacy. We investigated the potential of RNA interference (RNAi) therapies targeting hepatic angiotensinogen (AGT) for hypertension management.
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