Toward Network Biology in E. coli Cell.

Adv Exp Med Biol

Department of Biological Sciences, Purdue University, West Lafayette, IN, 47907, USA.

Published: April 2016

E. coli has been a critically important model research organism for more than 50 years, particularly in molecular biology. In 1997, the E. coli draft genome sequence was published. Post-genomic techniques and resources were then developed that allowed E. coli to become a model organism for systems biology. Progress made since publication of the E. coli genome sequence will be summarized.

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-319-23603-2_9DOI Listing

Publication Analysis

Top Keywords

model organism
8
genome sequence
8
coli
5
network biology
4
biology coli
4
coli cell
4
cell coli
4
coli critically
4
critically model
4
organism years
4

Similar Publications

Excessive total suspended matter (TSM) concentrations can exert a considerable impact on the growth of aquatic organisms in fishponds, representing a significant risk to aquaculture health. This study revised existing unified models using empirical data to develop an optimized TSM retrieval model tailored for the Guangdong-Hong Kong-Macao Greater Bay Area (GBA) (R = 0.69, RMSE = 7.

View Article and Find Full Text PDF

The recent emergence of bile salt hydrolase (BSH) enzyme as a therapeutic target reflects its unbound potential in mitigating hypercholesterolemia, obesity, and gastrointestinal issues. However, to bolster its industrial application, optimization of BSH assay lays the cornerstone for enhancing sensitivity, specificity, and reproducibility. The current study delved into optimizing the BSH assay parameters utilizing response surface methodology (RSM) and one-factor-at-a-time (OFAT) method for two novel, natural BSH producers, Heyndrickxia coagulans ATCC 7050 and Lactiplantibacillus plantarum ATCC 10012.

View Article and Find Full Text PDF

As one of the most commonly used general anesthetics (GAs) in surgery, numerous studies have demonstrated the detrimental effects of sevoflurane exposure on myelination in the developing and elderly brain. However, the impact of sevoflurane exposure on intact myelin structure in the adult brain is barely discovered. Here, we show that repeated sevoflurane exposure, but not single exposure, causes hypomyelination and abnormal ultrastructure of myelin sheath in the prefrontal cortex (PFC) of adult male mice, which is considered as a critical brain region for general anesthesia mediated consciousness change.

View Article and Find Full Text PDF

Background: Exposure to per- and polyfluoroalkyl substances (PFAS) has been linked with various cancers. Assessment of PFAS in drinking water and cancers can help inform biomonitoring and prevention efforts.

Objective: To screen for incident cancer (2016-2021) and assess associations with PFAS contamination in drinking water in the US.

View Article and Find Full Text PDF

UW supplementation with AP39 improves liver viability following static cold storage.

Sci Rep

January 2025

Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Static cold storage of donor livers at 4 °C incompletely arrests metabolism, ultimately leading to decreases in ATP levels, oxidative stress, cell death, and organ failure. Hydrogen Sulfide (HS) is an endogenously produced gas, previously demonstrated to reduce oxidative stress, reduce ATP depletion, and protect from ischemia and reperfusion injury. HS is difficult to administer due to its rapid release curve, resulting in cellular death at high concentrations.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!