AI Article Synopsis
- Huntington disease (HD) is associated with various symptoms, including motor, cognitive, and psychiatric issues, but also commonly includes sleep and circadian rhythm disturbances, often appearing before motor symptoms.
- Despite the prevalence of these disturbances in HD, there is a lack of studies investigating specific treatments for them.
- Potential treatment options drawn from research in similar neurodegenerative diseases like Parkinson's and Alzheimer's include melatonin and bright light therapy, but clinical trials are needed to confirm their effectiveness in HD.
Article Abstract
Aside from the well-known motor, cognitive and psychiatric signs and symptoms, Huntington disease (HD) is also frequently complicated by circadian rhythm and sleep disturbances. Despite the observation that these disturbances often precede motor onset and have a high prevalence, no studies are available in HD patients which assess potential treatments. In this review, we will briefly outline the nature of circadian rhythm and sleep disturbances in HD and subsequently focus on potential treatments based on findings in other neurodegenerative diseases with similarities to HD, such as Parkinson and Alzheimer disease. The most promising treatment options to date for circadian rhythm and sleep disruption in HD include melatonin (agonists) and bright light therapy, although further corroboration in clinical trials is warranted.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2217/nmt.15.45 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!