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Focused ion beam (FIB) prepared microtextured microneedle array capable of delivering drugs through punctured skin.
Sci Rep
December 2024
School of Mechanical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China.
Microtextured microneedles are tiny needle-like structures with micron-scale microtextures, and the drugs stored in the microtextures can be released after entering the skin to achieve the effect of precise drug delivery. In this study, the skin substitution model of Ogden's hyperelastic model and the microneedle array and microtexture models with different geometrical parameters were selected to simulate and analyse the flow of the microtexture microneedle arrays penetrating the skin by the finite-element method, and the length of the microneedles was determined to be 200 μm, the width 160 μm, and the value of the gaps was determined to be 420 μm. A four-pronged cone was chosen as the shape of microneedles, and a rectangle was chosen as the shape of the drug-carrying microneedle.
View Article and Find Full Text PDFValidation of Risk Prediction Models for Pneumothorax and Intercostal Catheter Insertion Following CT-Guided Lung Biopsy.
J Med Imaging Radiat Oncol
December 2024
Department of Radiology, Grampians Health, Ballarat Central, Victoria, Australia.
Background: CT-guided percutaneous transthoracic needle biopsy is the primary method for diagnosing lung lesions. Widely accepted validated risk prediction models are yet to be developed. A recently published study conducted at Grampians Health Services (GHS) developed two risk prediction models for predicting pneumothorax and intercostal catheter (ICC) insertion.
View Article and Find Full Text PDFA Combinatorial Approach with Microneedle Pretreatment and Thermosensitive Gel Loaded with Rivastigmine Lipid Nanoparticle Formulation Enables Brain Delivery via the Trigeminal Nerve.
ACS Appl Mater Interfaces
December 2024
Department of Chemistry, IPB University, Bogor 16680, West Java Indonesia.
Article Synopsis
- Alzheimer's disease leads to cognitive decline and increased care needs; Rivastigmine (RV) is a key treatment limited by the blood-brain barrier (BBB).
- A new method using polymeric microneedles (PMN) and a solid lipid nanoparticle-RV-loaded thermosensitive gel (PMN-SLN-RV-TG) shows potential for better brain delivery compared to traditional methods.
- The study found that PMN-SLN-RV-TG has improved penetration and pharmacokinetic parameters, yielding a higher brain-to-blood ratio and demonstrating safety for brain tissue, indicating a promising alternative for Alzheimer's treatment.
Development and optimization of hydrogel-forming microneedles fabricated with 3d-printed molds for enhanced dermal diclofenac sodium delivery: a comprehensive in vitro, ex vivo, and in vivo study.
Drug Deliv Transl Res
October 2024
Department of Pharmaceutical Technology, Faculty of Pharmacy, Gazi University, Ankara, Türkiye.
With the developing manufacturing technologies, the use of 3D printers in microneedle production is becoming widespread. Hydrogel-forming microneedles (HFMs), a variant of microneedles, demonstrate distinctive features such as a high loading capacity and controlled drug release. In this study, the conical microneedle master molds with approximately 500 μm needle height and 250 μm base diameter were created using a Stereolithography (SLA) 3D printer and were utilized to fabricate composite HFMs containing diclofenac sodium.
View Article and Find Full Text PDFOptimization and characterization of alginate/cinnamaldehyde electrosprayed microcapsule and its application to mongolian cheese preservation.
Int J Biol Macromol
December 2024
College of Food Science and Technology, Shanghai Ocean University, Shanghai, China. Electronic address:
alginate is a good candidate for encapsulating bioactive compounds because the Na on its carboxyl groups can take part in an ion exchange process with Ca to generate a calcium alginate shell. Electrospraying technology was used to prepare cinnamaldehyde (CA)-loaded alginate microcapsules. The generation of microcapsules with a minimal diameter could improve the mass transfer of encapsulated materials.
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