Different expression of miR-29b and VEGFA in glioma.

Artif Cells Nanomed Biotechnol

b Department of Neurosurgery , Xiangya Hospital, Central South University, Changsha , Hunan , P.R. China.

Published: December 2016

Glioma is one of the most common carcinomas in terms of both incidence and mortality worldwide. This is a case-control study with 240 cases and age- and gender-matched controls in the rate of 1:1. The results of this present word indicated that the expressions of both miR-29b and VEGFA in blood were significantly different compared with the control group, and thus may help to differentiate glioma cases from the controls. In addition, the diagnostic role of miR-29b and VEGFA was important for the clinical application. In conclusion, circulating miR-29b and VEGFA could be used as diagnosis biomarkers.

Download full-text PDF

Source
http://dx.doi.org/10.3109/21691401.2015.1111237DOI Listing

Publication Analysis

Top Keywords

mir-29b vegfa
16
expression mir-29b
4
vegfa
4
vegfa glioma
4
glioma glioma
4
glioma common
4
common carcinomas
4
carcinomas terms
4
terms incidence
4
incidence mortality
4

Similar Publications

Background: Abnormal endometrial blood flow causes a decrease in endometrial receptivity and is considered a relatively independent risk factor for recurrent implantation failure (RIF). This study aimed to explore the potentially functional circRNA-miRNA-mRNA network in RIF, and further explore its mechanism.

Methods: Datasets were downloaded from the GEO database to identify differentially expressed circRNAs, miRNAs and mRNAs.

View Article and Find Full Text PDF

Hydroxysafflor yellow A exerts anti-fibrotic and anti-angiogenic effects through miR-29a-3p/PDGFRB axis in liver fibrosis.

Phytomedicine

September 2024

State Key Laboratory of Southwestern Chinese Medicine Resources, Key Laboratory of Standardization for Chinese Herbal Medicine, Ministry of Education, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. Electronic address:

Background: Liver fibrosis is a prevalent pathological process in chronic liver diseases characterized by excessive extracellular matrix (ECM) deposition and abnormal angiogenesis. Notably, hepatic stellate cells (HSCs) are the primary source of ECM. Activated HSCs not only secrete numerous pro-fibrotic cytokines but also are endowed with a pro-angiogenic phenotype to promote pathological angiogenesis.

View Article and Find Full Text PDF

Backgrounds: Non-small cell lung carcinoma (NSCLC) is a common type of lung cancer. Prior investigations have elucidated the pivotal role of miR-29b-3p in restraining tumor growth and metastasis. Nonetheless, it remains to be determined whether miR-29b-3p can effectively suppress NSCLC progression and enhance the sensitivity of NSCLC cells to cisplatin.

View Article and Find Full Text PDF

Peptide OM-LV20 promotes arteriogenesis induced by femoral artery ligature via the miR-29b-3p/VEGFA axis.

Atherosclerosis

April 2024

Department of Anatomy & Histology & Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, 650500, Yunnan, China. Electronic address:

Article Synopsis
  • Therapeutic arteriogenesis shows promise for treating ischemic diseases due to atherosclerosis, but effective drug targets are still needed.
  • A study administered a peptide (OM-LV20) to rats with hindlimb ischemia, finding it increased collateral vessel growth and enhanced certain inflammatory responses, while influencing key signaling pathways in endothelial cells.
  • The research identified a microRNA (miR-29b-3p) that, when inhibited, improved the proliferation and migration of endothelial cells, suggesting that OM-LV20 could promote arteriogenesis through the miR-29b-3p/VEGFA/VEGFR2-PI3K/AKT/eNOS signaling pathway.
View Article and Find Full Text PDF

Comparative Analysis of miRNA and EMT Markers in Metastatic Colorectal Cancer.

Cancer Invest

December 2023

Department of Medical Biology and Genetics, Faculty of Medicine, Charles University, Czech Republic.

Colorectal cancer (CRC) is the fourth most commonly diagnosed malignant condition in the world. Micro RNAs (miRNAs) as well as epithelial to mesenchymal transition (EMT) play an important role in the pathogenesis of CRC. We performed a comparative analysis of the expression of selected miRNA genes and EMT markers in bioptic samples from patients (n = 45) with primary CRC or metastatic (m)CRC to the regional lymph node using reverse transcription-quantitative PCR and IHC staining.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!