AI Article Synopsis
- - This study aimed to analyze the antibiotic resistance of group B streptococci (GBS) found in late-pregnant women, highlighting the importance of effective antibiotic treatment for prevention and cure.
- - A total of 31 pregnant women were examined, revealing that 38.7% of GBS strains resisted clindamycin and 67.7% resisted erythromycin, with various resistance mechanisms identified through specific testing.
- - The findings indicate a concerning rate of antibiotic resistance in GBS, primarily driven by genetic changes affecting ribosomal targets and active drug efflux, emphasizing the need for vigilant antibiotic management strategies.
Article Abstract
Objective: To study the antibiotic-resistant rate of group B streptococci (GBS) in obstetric canal of late-pregnant women, evaluate the antibiotic-resistant status and finally to support the GBS prevention and curing by proper antibiotics.
Methods: 31 pregnant women between 35 to 37 gestational weeks were included, for whom the antibiotic sensitivity as well as the drug (erythromycin and clindamycin) resistance genes of GBS in obstetric canal was analyzed.
Results: 12 (38. 7%) strains of GBS were resistant to clindamycin, while 21 (67. 7%) to erythromycin, within which 12 strains were intrinsic phenotype - cMLS type-clindamycin resistance, other 9 were active efflux phenotype - MS type-clindamycin sensitive and all of which were confirmed by Double disk diffusion method. Eleven strains were mef (A) positive, and 12 strains were erm (B) positive, in which 3 with erm (C).
Conclusions: In our research the GBS strains show a high erythromycin and clindamycin resistance rate. The resistance of our GBS strains are mainly caused by the ribosomal target changes induced by erm (B) and the increased efflux of clindamycin induced by mef (A).
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