We retrospectively reviewed 14 children with active blastomycosis. Pulmonary disease occurred in 86% of the cohort and extrapulmonary dissemination was noted in 46%. Urine blastomycosis or histoplasmosis antigens were positive in all tested patients. Acute kidney injury was common in patients who were treated with amphotericin. Mortality tended to be associated with a delay in diagnosis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/jpids/pis107 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Genome-level therapeutic targets identification and chimeric Vaccine designing against the .
Heliyon
August 2024
Department of Intensive Care Unit, Changzhou Maternity and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, 213004, China.
Article Synopsis
- Blastomyces dermatitidis is a dangerous fungus that can cause life-threatening infections, particularly affecting the lungs and other body systems, yet no vaccines are currently approved to prevent it.
- A new peptide-based vaccine was developed using innovative techniques that involves analyzing the fungus's genome to identify effective targets and create multi-epitope constructs that enhance immune response.
- The vaccine demonstrated promising properties through simulations, showing a strong interaction with the human immune receptor and predicted significant immune responses, paving the way for future validation and potential use.
Disseminated Blastomycosis in an African American immunocompetent pediatric patient: Lessons learned.
Pediatr Dermatol
November 2023
Division of Dermatology, Department of Medicine, Phoenix Children's Hospital, Phoenix, Arizona, USA.
Disseminated blastomycosis can be challenging to diagnose given possible involvement of nearly any extrapulmonary organ system and the limitations of fungal diagnostic testing. Certain racial groups are at increased risk of disseminated fungal infections, even in immunocompetent patients. We describe a case of disseminated blastomycosis with cutaneous involvement in an African American adolescent with delayed diagnosis.
View Article and Find Full Text PDFEndemic mycoses in children in North America: a review of radiologic findings.
Pediatr Radiol
May 2023
Department of Radiology, MLC 5031, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA.
Clinically significant endemic mycoses (fungal infections) in the United States (U.S.) include Blastomyces dermatitidis, Histoplasma capsulatum, and Coccidioides immitis/posadasii.
View Article and Find Full Text PDFDiagnosis of Cutaneous Chromoblastomycosis and Its Response to Amphotericin B Therapy: A Case Report.
Cureus
August 2022
Obstetrics and Gynaecology, Hayatabad Medical Complex Peshawar, Peshawar, PAK.
Cutaneous chromoblastomycosis is a chronic subcutaneous fungal disease of the skin caused by , especially by , ,and species affecting the skin, lungs, intestines, stomach, and central nervous system. It is treated using itraconazole in mild cases and amphotericin B in severe cases. A six-year-old female child presented to the Dermatology Outpatient Department with pigmented brown to blackish tanned plaques and verrucous lesions on the face and extremities.
View Article and Find Full Text PDFImaging findings of pulmonary blastomycosis in pediatric patients.
Pediatr Radiol
September 2022
Department of Diagnostic Imaging, Health Science Center, Children's Hospital of Winnipeg, University of Manitoba, JM281-840 Sherbrook St., Winnipeg, MB, R2A 1S1, Canada.
Blastomycosis is caused by Blastomyces dermatitidis, a thermally dimorphic fungus that lives in the form of spores in the soil in North America. The main mode of transmission is through the inhalation of these spores. Despite the importance of knowing the imaging characteristics of blastomycosis given the suggested high rates of dissemination in symptomatic children, a paucity of literature focuses on the imaging patterns of blastomycosis in the pediatric population.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!