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http://dx.doi.org/10.1109/IWMPI.2015.7107011 | DOI Listing |
J Mater Chem B
January 2025
Department of Biomedical Technology, College of Applied Medical Sciences in Al-Kharj, Prince Sattam bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia.
Exosomes, which are considered nanoscale extracellular vesicles (EVs), are secreted by various cell types and widely distributed in different biological fluids. They consist of multifarious bioactive molecules and use systematic circulation for their transfer to adjoining cells. This phenomenon enables exosomes to take part in intercellular and intracellular communications.
View Article and Find Full Text PDFBMC Pharmacol Toxicol
December 2024
Comparative Medicine Institute, North Carolina State University, Raleigh, NC, USA.
Background: Local drug presentation made possible by drug-eluting depots provides benefits for a vast array of diseases, including cancer, microbial infection, and wound healing. Drug-eluting depots provide sustained drug release of therapeutics directly at disease sites with tunable kinetics, remove the need for drugs to access disease sites from circulation, and reduce the side effects associated with systemic therapy. Recently, we introduced an entirely novel approach to local drug presentation named Tissue-Reactive Anchoring Pharmaceuticals (TRAPs).
View Article and Find Full Text PDFColloids Surf B Biointerfaces
December 2024
College of Chemistry and Life Science, Sichuan Provincial Key Laboratory for Structural Optimization and Application of Functional Molecules, Chengdu Normal University, Chengdu 611130, China. Electronic address:
The surface characteristics of nanoparticles play a pivotal role in modulating the efficiency and functionality of drug delivery systems, particularly when addressing the complex challenges of targeted therapeutics. This study presents the development of a core-shell nanoparticle system (PMAA@DOX-PVA), incorporating poly(vinyl alcohol) (PVA) as a dynamic shell component to establish dual responsiveness to pH and glutathione levels. The hydrophilic PVA shell is covalently conjugated to the poly (methylacrylic acid) (PMAA) core via a boronic ester bond, establishing a robust platform for controlled release with tunable surface properties.
View Article and Find Full Text PDFNat Mater
January 2025
Nanotechnology and Advanced Spectroscopy Team, C-PCS, Chemistry Division, Los Alamos National Laboratory, Los Alamos, NM, USA.
Present-day liquid-state lasers are based on organic dyes. Here we demonstrate an alternative class of liquid lasers that use solutions of colloidal quantum dots (QDs). Previous efforts to realize such devices have been hampered by the fast non-radiative Auger recombination of multicarrier states required for optical gain.
View Article and Find Full Text PDFAcc Chem Res
December 2024
State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing 211198, China.
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