AI Article Synopsis
- GOLPH3 is identified as an oncoprotein potentially serving as a prognostic biomarker in various solid tumors.
- A meta-analysis comprising 15 studies and 2529 cases revealed that higher levels of GOLPH3 are linked to shorter overall survival (OS) and disease-free survival (DFS).
- Subgroup analysis indicated that GOLPH3 overexpression particularly correlates with worse OS in urogenital cancers, suggesting its role in predicting poor prognosis in solid tumors.
Article Abstract
Golgi phosphoprotein3 (GOLPH3) is known as an oncoprotein and may be a prognostic biomarker in various tumors. Here we performed a meta-analysis on the association of GOLPH3 expression and survival in solid tumors. All eligible studies were identified in Embase, PubMed and Web of Science Databases up to November 2014. Data about overall survival (OS), and disease-free survival (DFS) were extracted and pooled hazard ratios (HRs) of GOLPH3 for survival were calculated by using a random-effect model. Heterogeneity and publication bias were also assessed. A total of 15 eligible studies which comprised of 2529 cases were included in this global analysis: 14 were dealing with overall survival (OS) and 6 were with disease-free survival (DFS). We found that GOLPH3 overexpression was associated with shorter OS (HR 2.487, 95% CI 1.897-3.258, P < 0.001) and DFS (HR 1.911, 95% CI 1.245-2.932, P = 0.003) in general carcinomas. Importantly, subgroup analysis suggested that overexpression of GOLPH3 correlated with shorter OS in urogenital system cancers (HR 4.258, 95% CI 1.81-4.91, P < 0.001). Moreover, publication bias was not significant (P > 0.05). In conclusion, the present meta-analysis showed that overexpression of GOLPH3 predicts poor prognosis in solid tumors.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637586 | PMC |
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