E2F transcription factors regulate a wide range of biological processes, including cell cycle, apoptosis and DNA damage response. In the present study, we examined whether E2F2 is related to the poor prognosis of NSCLC and its role in progress of NSCLC. Firstly, we analyzed 86 NSCLC samples by immunohistochemistry and found that E2F2 expression was markedly increased in 62.8% (54/86) of all samples compared with the normal tissues. Further study showed that E2F2 expression was closely associated with clinical stage (P = 0.039) and tumor size (P = 0.045). Furthermore, Kaplan-Meier analysis indicated that high Bad expression was significantly correlated to overall survival (P = 0.045) but not disease-free survival (P = 0.288). In addition, our results showed that knockdown E2F2 expression could reduce cell viability and colony formation in NSCLC cells. The results in our study for the first time revealed that E2F2 act as an activator in tumor progress of NSCLC and could become a promising marker for the prognosis of patients with NSCLC.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637579 | PMC |
Publication Analysis
Top Keywords
Similar Publications
LncRNA PTS-1 Protects Against Osteoarthritis Through the miR-8085/E2F2 Axis.
J Inflamm Res
January 2025
Department of Orthopaedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
Background: Osteoarthritis (OA) is a leading cause of pain, disability, and reduced mobility worldwide, characterized by metabolic imbalances in chondrocytes, extracellular matrix (ECM), and subchondral bone. Emerging evidence highlights the critical role of long non-coding RNAs (lncRNAs) in OA pathogenesis. This study focuses on lncRNA PTS-1, a novel lncRNA, to explore its function and regulatory mechanisms in OA progression.
View Article and Find Full Text PDFRole of Cellular Senescence Genes and Immune Infiltration in Sepsis and Sepsis-Induced ARDS Based on Bioinformatics Analysis.
J Inflamm Res
November 2024
Intensive Care Unit, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Article Synopsis
- * Researchers analyzed gene expression data to identify key genes and pathways associated with sepsis and ARDS, using machine learning methods to pinpoint characteristic genes and assess their diagnostic potential.
- * Four genes (ATM, CCNB1, CCNA1, and E2F2) were identified as biomarkers related to sepsis-induced ARDS, with E2F2 showing the best predictive ability. The study also noted differences in immune cell types present in patients with sepsis-induced ARDS compared to
Long noncoding RNA bridges the DREAM complex and E2f1 to regulate endoreplication in .
Sci Adv
November 2024
School of Medicine, Nantong University, Nantong 226001, China.
Rb/E2f and DREAM complexes play vital roles in regulating cell cycle progression. To date, how they coordinate their functions to regulate cell cycle-dependent gene expression is not clear. Here, we identified a long noncoding RNA (lncRNA), which we named , that bridges the interaction between E2f1 and the dREAM complex to regulate endoreplication specifically in salivary gland.
View Article and Find Full Text PDFStudy of the Role of E2F1 and TMEM132A in Prostate Cancer Development.
Front Biosci (Landmark Ed)
October 2024
Department of Ultrasound, the Second Affiliated Hospital of Qiqihar Medical College, 161006 Qiqihar, Heilongjiang, China.
Objective: Identify transcription factors and target genes associated with prostate cancer, offering new therapy approaches.
Methods: Gene Set Enrichment Analysis (GSEA) investigates early 2 factor (E2F) transcription factor family roles in prostate cancer using the TCGA database. Survival analysis examined E2F factors and patient survival connections.
E2F2 Reprograms Macrophage Function By Modulating Material and Energy Metabolism in the Progression of Metabolic Dysfunction-Associated Steatohepatitis.
Adv Sci (Weinh)
December 2024
Affiliated Hospital of Xuzhou Medical University, Xuzhou, 220005, China.
Macrophages are essential for the development of steatosis, hepatic inflammation, and fibrosis in metabolic dysfunction-associated steatohepatitis(MASH). However, the roles of macrophage E2F2 in the progression of MASH have not been elucidated. This study reveals that the expression of macrophage E2F2 is dramatically downregulated in MASH livers from mice and humans, and that this expression is adversely correlated with the severity of the disease.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!