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| http://dx.doi.org/10.3389/fpsyg.2015.01719 | DOI Listing |
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KAN-EEG: towards replacing backbone-MLP for an effective seizure detection system.
R Soc Open Sci
March 2025
School of Biomedical Engineering, Faculty of Engineering, The University of Sydney, Sydney, NSW 2006, Australia.
The landscape of artificial intelligence (AI) research is witnessing a transformative shift with the emergence of the Kolmogorov-Arnold network (KAN), presenting a novel architectural paradigm aimed to redefine the structural foundations of AI models, which are based on multilayer perceptron (MLP). Through rigorous experimentation and evaluation, we introduce the KAN-electroencephalogram (EEG) model, a tailored design for efficient seizure detection. Our proposed network is tested and successfully generalized on three different datasets, one from the USA, one from Europe, and one from Oceania, recorded with different front-end hardware.
View Article and Find Full Text PDFInternal in-frame translation generates Cas11b, which is important for effective interference in an archaeal CRISPR-Cas system.
Front Microbiol
February 2025
Molecular Biology and Biotechnology of Prokaryotes, Ulm University, Ulm, Germany.
CRISPR-Cas is a sophisticated defence system used by bacteria and archaea to fend off invaders. CRISPR-Cas systems vary in their Cas protein composition and have therefore been divided into different classes and types. Type I systems of bacteria have been shown to contain the small protein Cas11 as part of the interference complex known as Cascade.
View Article and Find Full Text PDFBackground: In vitro oocyte maturation (IVM) is not a novel concept; however, its wide-scale practice has been limited because of the lower clinical outcomes compared to conventional assisted reproductive technologies.
Methods: This comprehensive review addresses the significant advances made in oocyte in vitro maturation with the biphasic capacitation (CAPA)-IVM strategy applied to small ovarian antral follicles in humans over the last 10 years. CAPA-IVM consists of a prematuration phase wherein immature oocytes are temporarily meiotically arrested to gain competence before undergoing meiotic resumption.
Off-the-Shelf Large Language Models for Causality Assessment of Individual Case Safety Reports: A Proof-of-Concept with COVID-19 Vaccines.
Drug Saf
March 2025
Department of Drug Design and Pharmacology, University of Copenhagen, Jagtvej 160, 2100, Copenhagen, Denmark.
Background: This study evaluated the feasibility of ChatGPT and Gemini, two off-the-shelf large language models (LLMs), to automate causality assessments, focusing on Adverse Events Following Immunizations (AEFIs) of myocarditis and pericarditis related to COVID-19 vaccines.
Methods: We assessed 150 COVID-19-related cases of myocarditis and pericarditis reported to the Vaccine Adverse Event Reporting System (VAERS) in the United States of America (USA). Both LLMs and human experts conducted the World Health Organization (WHO) algorithm for vaccine causality assessments, and inter-rater agreement was measured using percentage agreement.
Improving peer review of systematic reviews and related review types by involving librarians and information specialists as methodological peer reviewers: a randomised controlled trial.
BMJ Evid Based Med
March 2025
Department of Epidemiology, Maastricht University Care and Public Health Research Institute, Maastricht, The Netherlands.
Objective: To evaluate the impact of adding librarians and information specialists (LIS) as methodological peer reviewers to the formal journal peer review process on the quality of search reporting and risk of bias in systematic review searches in the medical literature.
Design: Pragmatic two-group parallel randomised controlled trial.
Setting: Three biomedical journals.
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