AI Article Synopsis
- Delusions are primarily recognized as a positive symptom of schizophrenia but can also occur in various other mental and neurological disorders.
- The complexity of delusions, combined with the absence of suitable animal models, makes it challenging to study them in isolation.
- This text proposes that the claustrum, a less-explored structure in the brain, may serve as a central hub for understanding delusional states, backed by existing research findings.
Article Abstract
Delusions are a hallmark positive symptom of schizophrenia, although they are also associated with a wide variety of other psychiatric and neurological disorders. The heterogeneity of clinical presentation and underlying disease, along with a lack of experimental animal models, make delusions exceptionally difficult to study in isolation, either in schizophrenia or other diseases. To date, no detailed studies have focused specifically on the neural mechanisms of delusion, although some studies have reported characteristic activation of specific brain areas or networks associated with them. Here, we present a novel hypothesis and extant supporting evidence implicating the claustrum, a relatively poorly understood forebrain nucleus, as a potential common center for delusional states.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639708 | PMC |
| http://dx.doi.org/10.3389/fpsyt.2015.00158 | DOI Listing |
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