AI Article Synopsis
- A new conjugate combining artesunate and podophyllotoxin was developed and tested for its effectiveness against various cancer cell lines using a CCK-8 assay.
- It demonstrated strong cytotoxic effects with IC50 values ranging from 0.453 to 3.011 μM, and helped reduce drug resistance in the cells.
- Additional findings showed that the conjugate disrupts microtubules, triggers G2/M cell cycle arrest, induces cancer cell death through apoptosis, and lowers levels of P-glycoprotein in resistant cancer cells.
Article Abstract
A novel conjugate of artesunate-podophyllotoxin was prepared and evaluated for its cytotoxicity against diverse normal and multidrug resistance human cancer cell lines by CCK-8 assay. The conjugate exhibited good cytotoxicity on all the cell lines with IC50 values of 0.453±0.156-3.011±0.272μM and reduced the resistant factor. The conjugate was further found to disrupt the microtubule network and induce G2/M cell cycle arrest in multidrug resistance K562/ADR cells. Meanwhile, Hoechst staining analysis suggested that conjugate induced cell death by apoptosis. Furthermore, conjugate could downregulate the levels of P-glycoprotein (P-gp) in P-gp overexpressing K562/ADR cells.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2015.11.042 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Improving Antibiotic Use in Argentine Pediatric Hospitals: A Process Evaluation Using Normalization Process Theory.
Pediatr Qual Saf
January 2025
Quality, Patient Safety and Clinical Management, Institute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina.
Introduction: In the pediatric setting, overprescribing of antibiotics contributes to the rise of multidrug-resistant organisms. Antimicrobial stewardship programs (ASPs) are recommended to optimize antibiotic use and combat resistance. However, the implementation of ASPs in low- and middle-income countries faces several challenges.
View Article and Find Full Text PDFEpigenetic Role of Long Non-coding RNAs in Multiple Myeloma.
Curr Oncol Rep
January 2025
Department of Molecular Oncology, Cancer Institute (WIA), Chennai, TN, India.
Purpose Of The Review: This review aims to explore the pivotal role of long non-coding RNAs (lncRNAs) as epigenetic regulators in the pathogenesis of multiple myeloma (MM). Additionally, we have portrayed the dual role of lncRNAs in the epigenetic landscape of MM pathobiology.
Recent Findings: In MM, lncRNAs are pivotal for proliferation, progression, and drug resistance by acting as miRNA sponges, regulating mRNA activity through microRNA recognition elements (MREs).
Antimicrobial Peptides Against Arboviruses: Mechanisms, Challenges, and Future Directions.
Probiotics Antimicrob Proteins
January 2025
Department of Virology, Pasteur Institute of Iran, Tehran, 13169-43551, Iran.
This review delves into the potential of antimicrobial peptides (AMPs) as promising candidates for combating arboviruses, focusing on their mechanisms of antiviral activity, challenges, and future directions. AMPs have shown promise in preventing arbovirus attachment to host cells, inducing interferon production, and targeting multiple viral stages, illustrating their multifaceted impact on arbovirus infections. Structural elucidation of AMP-viral complexes is explored to deepen the understanding of molecular determinants governing viral neutralization, paving the way for structure-guided design.
View Article and Find Full Text PDFA Novel Isotropic Optical Fiber: Antimicrobial Effect of Blue Light on Drug Resistant Organisms.
J Orthop Res
January 2025
Department of Orthopaedic Surgery, Division of Arthroplasty and Joint Reconstruction, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Drug-resistant organisms (DROs) necessitate the development of new therapies. Antimicrobial blue light (ABL) is a promising option, utilizing photoexcitation of endogenous bacterial components to generate reactive oxygen species, leading to bacterial death. The aim of this study is to investigate the effects of a novel isotropic optical fiber under in-vitro conditions on multidrug-resistant gram-negative Pseudomonas aeruginosa (MDR-Pa) and methicillin-resistant Staphylococcus aureus (MRSA).
View Article and Find Full Text PDFPioneering study of Egyptian Neem and Jojoba extracts with molecular docking combat hospital multidrug resistant bacteria.
Braz J Microbiol
January 2025
Department of Microbiology, Faculty of Science, Ain shams University, El-Khalyfa El-Mamoun Street, Abbasya, Cairo, Egypt.
Hospital surfaces are often contaminated with multidrug-resistant pathogenic bacteria that cause healthcare-associated infections and lead to increased mortality and morbidity. There is a need for new alternative antibacterial agents to overcome antibiotic resistance. Azadirachta indica and Simmondsia chinensis have been found to possess antibacterial activity and medicinal value.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!