AI Article Synopsis
- The study involves synthesizing new 2-, 4-, and 6-substituted hetaryl-3(5)-nitropyridines by reacting chlorosubstituted 3(5)-nitropyridine with diazoles or 3-chloropyridazin-6-one.
- Pyrazolyl-3-nitropyridine is created through the cyclization of hydrazinopyridine, formed via nucleophilic substitution of chlorine by hydrazine.
- The synthesized compounds show moderate antibacterial activity against specific Gram-positive and Gram-negative bacteria and demonstrate strong protistocidal effects, outperforming some existing clinically used medications.
Article Abstract
Reacting a number chlorosubstituted 3(5)-nitropyridine with some diazoles or 3-chloropyridazin-6-one synthesized previously undescribed various 2-, 4- or 6-substituted hetaryl-3(5)-nitropyridines. Furthermore, pyrazolyl-3-nitropyridine prepared by cyclizing hydrazinopyridine resulting from the nucleophilic substitution of chlorine in chlorosubstituted 3-nitropyridine by hydrazine. It has been shown that these compounds have moderate antibacterial activity against some pathogenic Gram-positive and Gram-negative bacteria (Staphylococcus aureus, Escherichia coli), as well as a strong effect on protistocidal action form Colpoda steinii, surpassing clinically used reference drugs.
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| http://dx.doi.org/10.1134/s1068162015030048 | DOI Listing |
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