A new antibacterial antibiotic, designated LL-E19085 alpha, was isolated from the fermentation broth of an actinomycete strain. Based on cultural, physiological, morphological and chemical characteristics, culture LL-E19085 was identified as a new subspecies of Micromonospora citrea. Antibiotic LL-E19085 alpha demonstrated potent activity against a spectrum of Gram-positive aerobic and anaerobic bacteria.
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Antibacterial activity of citreamicin-alpha (LL-E 19085 alpha) against gram-positive cocci.
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King Faisal Specialist Hospital, Riyadh, Saudi Arabia.
In vitro antibacterial activity of 429 clinical isolates of gram-positive cocci was tested against citreamicin-alpha (LL-E 19085-alpha) by the agar dilution method. The microorganisms consisted of 313 isolates of staphylococci and 116 strains of streptococci. In vitro activity of citreamicin-alpha was compared with ampicillin, augmentin, cephalothin, erythromycin and vancomycin.
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J Antibiot (Tokyo)
November 1991
Medical Research Division, American Cyanamid Company, Lederle Laboratories, Pearl River, New York 10965.
When the citreamicin-producing organism Micromonospora citrea NRRL 189351 was incubated in the presence of the methylation inhibitors sinefungin or aminopterin, biosynthesis of the zeta component was stimulated approximately 20 to 200-fold above the level normally produced. Inhibition of a second methylation reaction, which is superficially very similar to the first, was not detected. Other known methylation inhibitors failed to yield any change in the natural pattern of citreamicins produced.
View Article and Find Full Text PDFCitreamicins, novel antibiotics from Micromonospora citrea: isolation, characterization, and structure determination.
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Medical Research Division, American Cyanamid Company, Lederle Laboratories, Pearl River, New York 10965.
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View Article and Find Full Text PDFLL-E19085 alpha, a novel antibiotic from Micromonospora citrea: taxonomy, fermentation and biological activity.
J Antibiot (Tokyo)
June 1989
Medical Research Division, American Cyanamid Company, Lederle Laboratories, Pearl River, New York 10965.
A new antibacterial antibiotic, designated LL-E19085 alpha, was isolated from the fermentation broth of an actinomycete strain. Based on cultural, physiological, morphological and chemical characteristics, culture LL-E19085 was identified as a new subspecies of Micromonospora citrea. Antibiotic LL-E19085 alpha demonstrated potent activity against a spectrum of Gram-positive aerobic and anaerobic bacteria.
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