Evolution in antibiotic susceptibility of Bacteroides fragilis group strains in France based on periodic surveys.

Anaerobic antibiotic susceptibility testing with standardized methods enabled the authors to speculate on the evolution of antibiotic resistance within the Bacteroides fragilis group strains. Cefoxitin resistance was stable (0-5%) until 1985 and gradually increased later. Clindamycin resistance emerged in 1980 with a stable 10% resistance rate until 1986. An increase in clindamycin resistance developed in three institutions in 1987. No change was detected for imipenem and metronidazole, while piperacillin resistance increased since 1986. A comparison of antibiotic resistance rates is discussed for anaerobes in different countries.