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Objective: To investigate the evolution of prevalence of catastrophic health expenditure in the Brazilian Federal District at three different times (2003, 2009 and 2018), as well, to identify the composition of outof- pocket expenditure in the respective years.

Method: Time series study, using descriptive data from the Family Budget Survey. Prevalence was stratified by consumption quintiles.

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Using patient preference information (PPI) to incorporate patient voices into the drug development lifecycle can help align therapies with the needs and values of patients. However, several barriers have limited the use of PPI, including a lack of clarity on its use by decision-makers, a need for greater decision-maker trust in PPI, and a lack of time, budgets, and access to specialist expertise. The value proposition for PPI could be enhanced by making it FAIR: Findable, Accessible, Interoperable, and Reusable.

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Investigating the effects of urbanization at the county level on the balance of the carbon budget is essential for progress toward achieving "dual carbon" objectives at the county scale. Based on land use and economic data, this study elucidates the spatiotemporal evolution of urbanization and carbon budget balance ratio in 84 counties in Jiangxi Province from 1980 to 2020. Optimal geographic detectors and geographically weighted random forests were used to explore the impact of urbanization on the carbon budget balance ratio.

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Background And Aims: Population aging is associated with the rising incidence of chronic illness. This presents a significant challenge to healthcare systems, particularly in developing countries, as untreated chronic conditions can lead to years of disability and loss of independence straining health budgets and resources. Promoting healthy aging can be one avenue for mitigating these challenges.

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In the future, with elevated atmospheric CO (eCO), forests are expected to increase woody biomass to capture more carbon (C), though this is dependent on soil nutrient availability. While young forests may access unused nutrients by growing into an unexplored soil environment, it is unclear how or if mature forests can adapt belowground under eCO. Soil respiration ( ) and nutrient bioavailability are integrative ecosystem measures of below-ground dynamics.

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