AI Article Synopsis
- Acupuncture significantly reduced airway hyperresponsiveness (AHR), lung inflammation, and mucus secretion in a mouse model of asthma.
- The treatment led to lower levels of inflammatory cells (lymphocytes, eosinophils, and neutrophils) in lung fluid, as well as decreased OVA-specific IgE and Th17 cytokines (like IL-17A, IL-17F, IL-22) in the serum.
- Acupuncture also modified the balance of immune cells by increasing regulatory T cells (CD4+Foxp3+) and inhibiting certain inflammatory pathways, suggesting its therapeutic potential in managing asthma.
Article Abstract
Acupuncture is an effective therapeutic method in asthma treatment in traditional Chinese medicine. Here, we evaluated the effect of acupuncture on airway hyperresponsiveness (AHR) and the associated inflammatory changes as well as Th17 and Treg activity in ovalbumin- (OVA-) induced experimental asthma. Our results revealed that acupuncture treatment significantly inhibited AHR, lung inflammation, and mucus secretion of experimental asthma mice. Furthermore, a decrease in lymphocytes and eosinophils as well as neutrophils was observed in bronchoalveolar lavage fluid (BALF) of mice treated with acupuncture. Acupuncture reduced the OVA specific IgE level as well as the Th17 cytokine levels including IL-17A, IL-17F, and IL-22 in the serum of the experimental asthma mice. Acupuncture treatment group also had reduced CD4+IL-17A+ cell numbers and increased CD4+Foxp3+ cell numbers in BALF. In addition, acupuncture could inhibit IL-17R, RORγt, p65, and the inhibitor of NF-κB kinase-α (IKKα) protein expression. Our results indicated that acupuncture was effective in inhibiting AHR and inflammation in OVA-induced experimental asthma, which may be associated with the regulation of Th17 and Treg activity and NF-κB pathway.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646989 | PMC |
| http://dx.doi.org/10.1155/2015/340126 | DOI Listing |
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