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Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases. | LitMetric
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Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases.

Monica Sala-Rabanal Zeynep Yurtsever Kayla N Berry Tom J Brett

Mediators Inflamm

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA ; Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA ; Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA ; Drug Discovery Program in Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA ; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA.

Published: September 2016

Chloride transport proteins play critical roles in inflammatory airway diseases, contributing to the detrimental aspects of mucus overproduction, mucus secretion, and airway constriction. However, they also play crucial roles in contributing to the innate immune properties of mucus and mucociliary clearance. In this review, we focus on the emerging novel roles for a chloride channel regulator (CLCA1), a calcium-activated chloride channel (TMEM16A), and two chloride exchangers (SLC26A4/pendrin and SLC26A9) in chronic inflammatory airway diseases.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647060PMC
http://dx.doi.org/10.1155/2015/497387DOI Listing

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