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Functional anti-inflammatory mesoporous silica nanoplatform for Synergistic and Targeted abdominal aortic aneurysm treatment.
J Colloid Interface Sci
December 2024
Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China. Electronic address:
Abdominal aortic aneurysm (AAA) is a chronic inflammation-driven disease characterized by aortic wall destruction and expansion, leading to high morbidity and mortality. However, previous drug treatments for its common risk factors have not achieved favorable results, and the early prevention and treatment is still the main clinical dilemma. Anti-inflammation therapy is a promising therapeutical method targeting its pathogenesis mechanism, but it has not been explored in depth.
View Article and Find Full Text PDFEnhanced Vascular Smooth Muscle Cell and Extracellular Matrix Repair Using a Metal-Organic Framework-Based Co-Delivery System for Abdominal Aortic Aneurysm Therapy.
Adv Healthc Mater
December 2024
Department of Vascular Surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027, P. R. China.
The abdominal aortic aneurysm (AAA) is a severe and complex condition characterized by the pathological dilation of the abdominal aorta. Current therapeutic strategies are limited, with surgical repair being the most effective intervention due to the lack of medications that can slow aneurysmal expansion or prevent adverse events. In this study, an innovative nanoplatform, Mn-UiO-66-NH@HA, designed to repair vascular smooth muscle cells (VSMCs), and the extracellular matrix (ECM) is developed, thereby enhancing arterial wall integrity.
View Article and Find Full Text PDFCXCR4-targeted sensitive magnetic particle imaging for abdominal aortic aneurysm early detection and prognosis evaluation by recognizing total inflammatory cells.
Cardiovasc Res
December 2024
Department of Vascular Surgery, 2nd Hospital of Shanxi Medical University, No. 382, Wuyi road, Taiyuan, China.
Background: The maximum aortic diameter remains the diagnostic criteria and the indicator for prognosis prediction of abdominal aortic aneurysms (AAA). An additional imaging modality is currently needed to help evaluate the prognosis of AAA as well as early detection of AAA formation. This study evaluated the most effective inflammatory markers for AAA using single-cell sequencing and, from these, developed probes to facilitate in vivo multimodal imaging of AAA inflammation.
View Article and Find Full Text PDFIliac branch endoprosthesis for endovascular treatment of complex aorto-iliac aneurysms - from device design to practical experience: how to translate physiology considerations into clinical applications.
Exp Physiol
November 2024
Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, UK.
Article Synopsis
- - This article reviews current literature and expert opinions on using iliac branch endoprosthesis (IBE) for treating complex abdominal aortic aneurysms (AAA) that also involve the iliac arteries.
- - Around 25% of AAA patients have aneurysms that extend into ilac vessels, complicating standard endovascular aortic repair (EVAR) procedures and requiring careful assessment to ensure proper treatment.
- - The IBE is shown to be an effective and durable treatment option for complex aorto-iliac aneurysms, offering results comparable to open surgery but with lower risks, while also preserving pelvic circulation to avoid potential complications.
A Revolutionary Device for Endovascular Aortic Repair of Abdominal Aortic Aneurysm: A Pilot Study.
F1000Res
November 2024
Department of Cardiology and Vascular Medicine, Faculty of Medicine University of Indonesia, University of Indonesia Academic Hospital, National Cardiovascular Center Harapan Kita, Jakarta, Jakarta, 11420, Indonesia.
Article Synopsis
- Endovascular repair for abdominal aortic aneurysms (AAA) has been the preferred method since 1991, with new techniques like contralateral gate cannulation being developed to enhance the process.
- A new device called the Taofan and Kang (T&K) bidirectional endovascular aortic repair (B-EVAR) was introduced, utilizing a unique approach to deploy stent grafts through both femoral arteries while ensuring safety and effectiveness.
- In a pilot study involving six patients, the T&K B-EVAR showed promising results with no complications or prolonged hospital stays, indicating it simplifies the AAA repair process and could be beneficial for a wider range of patients.
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