AI Article Synopsis
- The study investigates how calf-thymus DNA (ctDNA) interacts with a probe made from the cationic dye phenosafranin (PSF) and the anionic lipid dimyristoyl-L-α-phosphatidylglycerol (DMPG) using various spectroscopic methods.
- It was found that in the presence of DNA, the probe detaches from its lipid environment and becomes embedded within the DNA helix.
- The research suggests that the anionic lipid has potential use as a nanocarrier for delivering cationic drugs directly to DNA, highlighting its role in drug delivery systems.
Article Abstract
The effect of calf-thymus DNA (ctDNA) on the lipid bound probe, formed by the cationic phenazinium dye phenosafranin (PSF) and the anionic lipid dimyristoyl-L-α-phosphatidylglycerol (DMPG), has been unearthed exploiting various spectroscopic techniques. Steady state and time-resolved fluorometric studies and measurements of circular dichroism and DNA helix melting temperature reveal that in the presence of DNA the probe is dislodged from the lipid environment and gets intercalated within the DNA helix. The work qualitatively illustrates that the anionic lipid can be used as a potential nanocarrier for delivering the cationic drugs to the most relevant biomacromolecular target, DNA.
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| http://dx.doi.org/10.1016/j.jphotobiol.2015.11.001 | DOI Listing |
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