As a group, we met to discuss the current challenges for creating meaningful patient-specific in vitro models to study brain disorders. Although the convergence of findings between laboratories and patient cohorts provided us confidence and optimism that hiPSC-based platforms will inform future drug discovery efforts, a number of critical technical challenges remain. This opinion piece outlines our collective views on the current state of hiPSC-based disease modeling and discusses what we see to be the critical objectives that must be addressed collectively as a field.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881284 | PMC |
| http://dx.doi.org/10.1016/j.stemcr.2015.10.011 | DOI Listing |
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