AI Article Synopsis
- Blocking IL-10 signaling during HPV long E7 peptide/LPS immunization helps shrink established HPV-16 tumors in mice, similar to using incomplete Freund's adjuvant (IFA) for vaccination.
- This study shows that this blockade results in stronger T cell responses and better immune cell infiltration compared to using IFA.
- Combining long E7 peptide/LPS with IL-10 blockade for initial priming, followed by a boost with long E7 peptide/IFA, may improve CD8+ T cell responses and enhance tumor regression in HPV-related cases.
Article Abstract
We recently reported that blockade of IL-10 signalling at the time of a human papillomavirus (HPV) long E7 peptide/LPS immunization leads to the regression of established HPV-16 immortalized tumours in mice similar to that induced by long E7 peptide/incomplete Freund's adjuvant (IFA)-based vaccination. In this paper, we demonstrated that blockade of IL-10 signalling at the time of long E7 peptide/LPS could elicit stronger T cells responses and render the tumour more accessible for immune cell infiltration than vaccination with long E7 peptide/IFA. Furthermore, priming with long E7 peptide/LPS and IL10 signalling blockade then boosting with long E7 peptide/IFA elicits stronger CD8+ T cell responses than long E7 peptide/IFA immunization. The results suggest that priming with long E7 peptide/LPS and IL10 signalling inhibitor, then boosting with long E7 peptide/IFA elicits may lead to better HPV infection related tumour regression in clinic.
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| http://dx.doi.org/10.1016/j.cellimm.2015.11.002 | DOI Listing |
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