The use of nanotechnology for drug delivery in cancer therapy has raised high expectations. Additionally, the use of nanomaterials in sensors to extract and detect tumor specific biomarkers, circulating tumor cells, or extracellular vesicles shed by the tumor holds the promise to detect cancer much earlier and hence improve long-term survival of the patients. Moreover, the monitoring of the anticancer drug concentration, which has a narrow therapeutic window, will allow for a personalized dosing of the drug and will lead to improved therapeutic outcome and life quality of the patient. This review will provide an overview on the use of nanosensors for the early diagnosis of cancer and for the therapeutic drug monitoring, giving some examples. We envision nanosensors to make significant improvements in the cancer management as easy-to-use point-of-care devices for a broad population of users.
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http://dx.doi.org/10.2217/nnm.15.180 | DOI Listing |
Brain Res
January 2025
Department of Chemistry and Biochemistry, Ohio University, Athens, OH, United States. Electronic address:
Autism spectrum disorder, or autism, is a neurodevelopmental disorder of the developing child's brain with a genetic causality. It can be diagnosed at about three years after birth when it begins to present itself via a range of neuropsychiatric symptoms. Nitric oxide is a crucial small molecule of life synthesized within cells of our body systems, including cells of our brain.
View Article and Find Full Text PDFEur J Dent
December 2024
Department of Dentistry, Oral Health Institute, Hamad Medical Corporation, Doha, Qatar, College of Dental Medicine, Qatar University, Doha, Qatar.
Advances in the field of nanomaterials are laying the foundation for the fabrication of nanosensors that are sensitive, selective, specific, cost-effective, biocompatible, and versatile. Being highly sensitive and selective, nanosensors are crucial in detecting small quantities of analytes and early diagnosis of diseases. These devices, operating on the nanoscale, detect signals, such as physical, chemical, optical, electrochemical, or biological, and then transduce them into a readable form.
View Article and Find Full Text PDFAdv Sci (Weinh)
December 2024
Department of Agriculture, Forestry and Bioresources, Seoul National University, Seoul, 08826, Republic of Korea.
Plants communicate through volatile organic compounds (VOCs), but real-time monitoring of VOCs for plant intercommunication is not practically possible yet. A nanobionic VOC sensor plant is created to study VOC-mediated plant intercommunication by incorporating surface-enhanced Raman scattering (SERS) nanosensors into a living plant. This sensor allows real-time monitoring of VOC with a sensitivity down to the parts per trillion level.
View Article and Find Full Text PDFJ Biophotonics
December 2024
Nanosensors and Clean Energy Laboratory, PSG Institute of Advanced Studies, Coimbatore, India.
ACS Sens
December 2024
School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Breath sensors promise early disease diagnosis through noninvasive, rapid analysis, but have struggled to reach clinical use due to challenges in scalability and multivariate data extraction. The current breath sensor design necessitates various channel materials and surface functionalization methods, which delays the process. Additionally, the limited options for channel materials that provide optimum sensitivity and selectivity further restrict the array size to a maximum of only 10 to 20 channels.
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