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Holistic monitoring of Campylobacter jejuni biofilms with NanoLuc bioluminescence.
Appl Microbiol Biotechnol
December 2024
Biotechnical Faculty, Department of Food Science and Technology, University of Ljubljana, Ljubljana, Slovenia.
Campylobacter jejuni, a major cause of foodborne zoonotic infections worldwide, shows a paradoxical ability to survive despite its susceptibility to environmental and food-processing stressors. This resilience is likely due to the bacterium entering a viable but non-culturable state, often within biofilms, or even initiating biofilm formation as a survival strategy. This study presents an innovative application of NanoLuc bioluminescence to accurately monitor the development of C.
View Article and Find Full Text PDFSTOUT V2.0: SMILES to IUPAC name conversion using transformer models.
J Cheminform
December 2024
Institute for Inorganic and Analytical Chemistry, Friedrich Schiller University Jena, Lessingstr. 8, 07743, Jena, Germany.
Naming chemical compounds systematically is a complex task governed by a set of rules established by the International Union of Pure and Applied Chemistry (IUPAC). These rules are universal and widely accepted by chemists worldwide, but their complexity makes it challenging for individuals to consistently apply them accurately. A translation method can be employed to address this challenge.
View Article and Find Full Text PDFAssociation of PD-1 + Treg/PD-1 + CD8 ratio and tertiary lymphoid structures with prognosis and response in advanced gastric cancer patients receiving preoperative treatment.
J Transl Med
December 2024
Department of Gastrointestinal Surgery, School of Medicine, RenJi Hospital, Shanghai Jiao Tong University, 160 Pujian Road, Pudong New Area, Shanghai, 200025, China.
Background: Recent studies have highlighted the distinct ratio of PD-1 + Treg/PD-1 + CD8 for prognosis prediction. However, it remains unclear about the association of this ratio and tertiary lymphoid structures (TLS) with prognosis and response to neoadjuvant or conversion therapy in advanced gastric cancer.
Methods: Firstly, fresh postoperative samples from 68 gastric cancer patients in Renji Hospital were collected.
Data-driven assessment of well stimulation in unconventional gas reservoirs.
Sci Rep
December 2024
School of Oil & Natural Gas Engineering, SouthWest Petroleum University, Chengdu, 610500, China.
Unconventional gas reservoirs, characterized by their complex geologies and challenging extraction conditions, demand innovative approaches to enhance gas production and ensure economic viability. Well stimulation techniques, such as hydraulic fracturing and acidizing, have become indispensable tools in unlocking the potential of these tight formations. However, the effectiveness of these techniques can vary widely depending on the specific characteristics of the reservoir.
View Article and Find Full Text PDFDeep reinforcement learning and fuzzy logic controller codesign for energy management of hydrogen fuel cell powered electric vehicles.
Sci Rep
December 2024
Department of Mechanical Engineering, Politecnico di Milano, Milan, Italy.
Hydrogen-based electric vehicles such as Fuel Cell Electric Vehicles (FCHEVs) play an important role in producing zero carbon emissions and in reducing the pressure from the fuel economy crisis, simultaneously. This paper aims to address the energy management design for various performance metrics, such as power tracking and system accuracy, fuel cell lifetime, battery lifetime, and reduction of transient and peak current on Polymer Electrolyte Membrane Fuel Cell (PEMFC) and Li-ion batteries. The proposed algorithm includes a combination of reinforcement learning algorithms in low-level control loops and high-level supervisory control based on fuzzy logic load sharing, which is implemented in the system under consideration.
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